Dedifferentiation: inspiration for devising engineering strategies for regenerative medicine
Y Yao, C Wang - NPJ Regenerative medicine, 2020 - nature.com
Cell dedifferentiation is the process by which cells grow reversely from a partially or
terminally differentiated stage to a less differentiated stage within their own lineage. This …
terminally differentiated stage to a less differentiated stage within their own lineage. This …
Characterization of ferroptosis-triggered pyroptotic signaling in heart failure
Pressure overload–induced cardiac hypertrophy is a common cause of heart failure (HF),
and emerging evidence suggests that excessive oxidized lipids have a detrimental effect on …
and emerging evidence suggests that excessive oxidized lipids have a detrimental effect on …
Unfolded protein response as a therapeutic target in cardiovascular disease
Cardiovascular disease is the leading cause of death worldwide. Despite overwhelming
socioeconomic impact and mounting clinical needs, our understanding of the underlying …
socioeconomic impact and mounting clinical needs, our understanding of the underlying …
Integrated stress response couples mitochondrial protein translation with oxidative stress control
Background: The integrated stress response (ISR) is an evolutionarily conserved process to
cope with intracellular and extracellular disturbances. Myocardial infarction is a leading …
cope with intracellular and extracellular disturbances. Myocardial infarction is a leading …
ATF4 protects the heart from failure by antagonizing oxidative stress
Background: Cellular redox control is maintained by generation of reactive oxygen/nitrogen
species balanced by activation of antioxidative pathways. Disruption of redox balance leads …
species balanced by activation of antioxidative pathways. Disruption of redox balance leads …
Targeting miR-30d reverses pathological cardiac hypertrophy
J Li, Z Sha, X Zhu, W Xu, W Yuan, T Yang, B Jin… - …, 2022 - thelancet.com
Background Pathological cardiac hypertrophy occurs in response to numerous stimuli and
precedes heart failure (HF). Therapies that ameliorate pathological cardiac hypertrophy are …
precedes heart failure (HF). Therapies that ameliorate pathological cardiac hypertrophy are …
Chronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodeling
The hexosamine biosynthetic pathway (HBP) plays critical roles in nutrient sensing, stress
response, and cell growth. However, its contribution to cardiac hypertrophic growth and …
response, and cell growth. However, its contribution to cardiac hypertrophic growth and …
Lactate dehydrogenase A governs cardiac hypertrophic growth in response to hemodynamic stress
The heart manifests hypertrophic growth in response to high blood pressure, which may
decompensate and progress to heart failure under persistent stress. Metabolic remodeling is …
decompensate and progress to heart failure under persistent stress. Metabolic remodeling is …
PKM1 exerts critical roles in cardiac remodeling under pressure overload in the heart
Background: Metabolic remodeling precedes most alterations during cardiac hypertrophic
growth under hemodynamic stress. The elevation of glucose utilization has been recognized …
growth under hemodynamic stress. The elevation of glucose utilization has been recognized …
Mesencephalic astrocyte–derived neurotrophic factor is an ER-resident chaperone that protects against reductive stress in the heart
A Arrieta, EA Blackwood, WT Stauffer… - Journal of Biological …, 2020 - ASBMB
We have previously demonstrated that ischemia/reperfusion (I/R) impairs endoplasmic
reticulum (ER)-based protein folding in the heart and thereby activates an unfolded protein …
reticulum (ER)-based protein folding in the heart and thereby activates an unfolded protein …