Background The dietary consumption of cuprizone–a copper chelator–has long been known
to induce demyelination of specific brain structures and is widely used as model of multiple …

The cuprizone mouse model allows the investigation of the complex molecular mechanisms
behind nonautoimmune-mediated demyelination and spontaneous remyelination. While it is …

Lysophosphatidylcholine (LPC) and lysophosphatidic acid (LPA), the most prominent
lysoglycerophospholipids, are emerging as a novel class of inflammatory lipids, joining …

Introduction: Demyelinating diseases of the central nervous system (CNS) comprise a group
of neurological disorders characterized by progressive (and eventually irreversible) loss of …

T2*-weighted gradient-echo MRI images at high field (≥ 7T) have shown rich image
contrast within and between brain regions. The source for these contrast variations has been …

Multiple sclerosis (MS) is a progressive chronic inflammatory autoimmune disease of the
myelin sheath, and melatonin is a powerful antioxidant and anti-inflammatory agent. The …

Based on increasing evidence suggesting that MS pathology involves alterations in
bioactive lipid metabolism, the present analysis was aimed at generating a complex serum …

Multiple sclerosis is characterized by inflammatory processes occurring within the central
nervous system. In multiple sclerosis, inflammation could be either a physiological response …

Multiple sclerosis (MS) is a chronic demyelinating disease of unknown etiology in which
tissue pathology suggests both immune-dependent attacks to oligodendroglia and primary …

Background Arachidonic acid metabolism by cyclooxygenase (COX) is a major pathway for
blood platelets' activation, which is associated with pro-thrombotic platelet activity and the …