The complexity of Alzheimer's disease: an evolving puzzle

C Ferrari, S Sorbi - Physiological reviews, 2021 - journals.physiology.org
The history of Alzheimer's disease (AD) started in 1907, but we needed to wait until the end
of the century to identify the components of pathological hallmarks and genetic subtypes and …

Understanding and predicting the longitudinal course of dementia

RJF Melis, ML Haaksma… - Current opinion in …, 2019 - journals.lww.com
It became clear that dementia progresses very differently, both between and within
individuals. This implies an average trajectory is not informative to individual persons and …

Identifying and evaluating clinical subtypes of Alzheimer's disease in care electronic health records using unsupervised machine learning

N Alexander, DC Alexander, F Barkhof… - BMC Medical Informatics …, 2021 - Springer
Background Alzheimer's disease (AD) is a highly heterogeneous disease with diverse
trajectories and outcomes observed in clinical populations. Understanding this …

Modifiable, non-modifiable, and clinical factors associated with progression of Alzheimer's disease

DA Loeffler - Journal of Alzheimer's Disease, 2021 - content.iospress.com
There is an extensive literature relating to factors associated with the development of
Alzheimer's disease (AD), but less is known about factors which may contribute to its …

The dual role of cognitive reserve in subjective cognitive decline and mild cognitive impairment: a 7-year follow-up study

S Mazzeo, S Padiglioni, S Bagnoli, L Bracco… - Journal of …, 2019 - Springer
The aim of this study was to evaluate the effect of cognitive reserve (CR), in progression from
subjective cognitive decline (SCD) to mild cognitive impairment (MCI) and Alzheimer's …

[HTML][HTML] Feature selection using efficient fusion of Fisher Score and greedy searching for Alzheimer's classification

MN KP, P Thiyagarajan - Journal of King Saud University-Computer and …, 2022 - Elsevier
Alzheimer's disease is one of the deadly progressive neurodegenerative diseases among
aged populations. But, the progression of the disease can be reduced by proper treatment of …

Genome‐wide association study of rate of cognitive decline in Alzheimer's disease patients identifies novel genes and pathways

R Sherva, A Gross, S Mukherjee… - Alzheimer's & …, 2020 - Wiley Online Library
Introduction Variability exists in the disease trajectories of Alzheimer's disease (AD) patients.
We performed a genome‐wide association study to examine rate of cognitive decline (ROD) …

A double-blind randomized controlled trial combining cognitive training (CoRe) and neurostimulation (tDCS) in the early stages of cognitive impairment

C Rodella, S Bernini, S Panzarasa, E Sinforiani… - Aging Clinical and …, 2022 - Springer
Background The prevalence of neurodegenerative diseases is expected to increase over
the next years, therefore, new methods able to prevent and delay cognitive decline are …

Aspirin use on incident dementia and mild cognitive decline: a systematic review and meta-analysis

H Li, W Li, X Zhang, XC Ma, RW Zhang - Frontiers in Aging …, 2021 - frontiersin.org
Background: More people with cognitive dysfunction and dementia also fall into the category
of high vascular risk, for which aspirin is one of the most frequently used drugs. However …

Imaging and spectral characteristics of amyloid plaque autofluorescence in brain slices from the APP/PS1 mouse model of Alzheimer's disease

Y Gao, Q Liu, L Xu, N Zheng, X He, F Xu - Neuroscience bulletin, 2019 - Springer
Amyloid deposits are one of the hallmark pathological lesions of Alzheimer's disease (AD).
They can be visualized by thioflavin-S, silver impregnation, Congo red staining, and …