Microsatellite instability (MSI) is a hypermutable phenotype caused by the loss of DNA
mismatch repair activity. MSI is detected in about 15% of all colorectal cancers; 3% are of …

Four main DNA mismatch repair (MMR) genes have been identified, MLH1, MSH2, MSH6,
and PMS2, which when mutated cause susceptibility to Lynch syndrome (LS). LS is one of …

Lynch syndrome patients are susceptible to colorectal and endometrial cancers owing to
inactivating germline mutations in mismatch repair genes, including MSH2 (ref.). Here we …

Lynch syndrome (LS) is one of the most prevalent hereditary cancer syndromes in humans
and accounts for some 3% of unselected patients with colorectal or endometrial cancer and …

Background Lynch syndrome is caused by germline mutations in MSH2, MLH1, MSH6, and
PMS2 mismatch-repair genes and leads to a high risk of colorectal and endometrial cancer …

BACKGROUND & AIMS: Colorectal cancers (CRCs) with microsatellite instability (MSI) and
a mismatch repair (MMR) immunohistochemical deficit without hypermethylation of the …

Hereditary ovarian cancer accounts for at least 5% of the estimated 22,000 new cases of this
disease during 2009. During this same time, over 15,000 will die from malignancy ascribed …

Genetic instability is one of the principal hallmarks and causative factors in cancer. Human
transposable elements (TE) have been reported to cause human diseases, including …

Lynch syndrome (clinically referred to as HNPCC–Hereditary Non-Polyposis Colorectal
Cancer) is a frequent, autosomal, dominantly-inherited cancer predisposition syndrome …

The aim of this study was to estimate the contribution of deleterious mutations in BRCA1,
BRCA2, MLH1, MSH2, MSH6 and PMS2 to invasive epithelial ovarian cancer (EOC) in the …