CD26/DPP4-a potential biomarker and target for cancer therapy

N Enz, G Vliegen, I De Meester… - Pharmacology & …, 2019 - Elsevier
Abstract CD26/dipeptidyl peptidase (DPP) 4 is a membrane-bound protein found in many
cell types of the body, and a soluble form is present in body fluids. There is longstanding …

DPPIV/CD26: a tumor suppressor or a marker of malignancy?

A Beckenkamp, S Davies, JB Willig, A Buffon - Tumor Biology, 2016 - Springer
Abstract Dipeptidyl peptidase IV (DPPIV/CD26) is a multifunctional protein with intrinsic
peptidase activity that inactivates or degrades some bioactive peptides. It is the main cellular …

Downregulating CD26/DPPIV by apigenin modulates the interplay between Akt and Snail/Slug signaling to restrain metastasis of lung cancer with multiple EGFR …

JH Chang, CW Cheng, YC Yang, WS Chen… - Journal of Experimental …, 2018 - Springer
Background Metastasis rather than the primary cancer determines the survival of cancer
patients. Activation of Akt plays a critical role in the epithelial-to-mesenchymal transition …

Suppression of lung metastases by the CD26/DPP4 inhibitor Vildagliptin in mice

JH Jang, L Baerts, Y Waumans, I De Meester… - Clinical & experimental …, 2015 - Springer
Metastases rather than primary cancers determine nowadays the survival of patients. One of
the most common primary malignancies is colorectal cancer and this type of tumor is …

Dipeptidyl peptidase in autoimmune pathophysiology

K Ohnuma, O Hosono, NH Dang… - Advances in clinical …, 2011 - books.google.com
CD26 is a 110-kDa surface glycoprotein with intrinsic dipeptidyl peptidase IV (DPPIV)
activity that is expressed on various cell types and has many biological functions. An …

Sitagliptin exhibits protective effects against methotrexate-induced testicular toxicity: The involvement of oxidative stress-related factors

MR Khezri, MR Pashaei, M Ghasemnejad-Berenji… - Reproductive …, 2024 - Elsevier
Methotrexate (MTX) is widely prescribed to treat different malignancies as well as
autoimmune diseases. However, it causes a range of side effects in different organs such as …

CD26 and asthma: a comprehensive review

JJ Nieto-Fontarigo, FJ González-Barcala… - Clinical Reviews in …, 2019 - Springer
Asthma is a heterogeneous and chronic inflammatory family of disorders of the airways with
increasing prevalence that results in recurrent and reversible bronchial obstruction and …

Dipeptidyl peptidase 4 promotes epithelial cell transformation and breast tumourigenesis via induction of PIN1 gene expression

HJ Choi, JY Kim, SC Lim, G Kim… - British journal of …, 2015 - Wiley Online Library
Background and Purpose Dipeptidyl peptidase 4 (DPP4) is an aminopeptidase that is widely
expressed in different cell types. Recent studies suggested that DPP4 plays an important …

[PDF][PDF] A novel role for CD26/dipeptidyl peptidase IV as a therapeutic target

K Ohnuma, R Hatano, E Komiya… - Front Biosci …, 2018 - article.imrpress.com
1754 A novel role for CD26/dipeptidyl peptidase IV as a therapeutic target Kei Ohnuma1, Ryo
Hatano1, Eriko Komiya1, Haruna Otsuk Page 1 1754 A novel role for CD26/dipeptidyl peptidase …

CD26 expression on T helper populations and sCD26 serum levels in patients with rheumatoid arthritis

OJ Cordero, R Varela-Calviño, T López-González… - Plos one, 2015 - journals.plos.org
We studied dipeptidyl peptidase IV (DPP-IV, CD26) expression in different T helper cells and
serum soluble DPP-IV/sCD26 levels in rheumatoid arthritis (RA) patients, correlated these …