Regulation of sexually dimorphic expression of major urinary proteins

DJ Penn, SM Zala, KC Luzynski - Frontiers in Physiology, 2022 - frontiersin.org
Male house mice excrete large amounts of protein in their urinary scent marks, mainly
composed of Major Urinary Proteins (MUPs), and these lipocalins function as pheromones …

Exposure to persistent organic pollutants: Impact on women's health

B Wahlang - Reviews on environmental health, 2018 - degruyter.com
This literature review focuses on the causal relationship between persistent organic
pollutants (POPs) exposure and women's health disorders, particularly cancer, cardio …

[HTML][HTML] Single-nuclei RNA sequencing assessment of the hepatic effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin

R Nault, KA Fader, S Bhattacharya… - Cellular and Molecular …, 2021 - Elsevier
Background and Aims Characterization of cell specific transcriptional responses to
hepatotoxicants is lost in the averages of bulk RNA-sequencing (RNA-seq). Single …

Single-cell transcriptomics shows dose-dependent disruption of hepatic zonation by TCDD in mice

R Nault, S Saha, S Bhattacharya, S Sinha… - Toxicological …, 2023 - academic.oup.com
Abstract 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) dose-dependently induces the
development of hepatic fat accumulation and inflammation with fibrosis in mice initially in the …

[HTML][HTML] Low dose exposure to dioxins alters hepatic energy metabolism and steatotic liver disease development in a sex-specific manner

OE Bolatimi, Y Hua, FA Ekuban, TC Gripshover… - Environment …, 2024 - Elsevier
Abstract “Dioxins” are persistent organic pollutants (POPs) that are continuously present in
the environment at appreciable levels and have been associated with increased risk of …

[PDF][PDF] Alcohol‐associated fibrosis in females is mediated by female‐specific activation of lysine demethylases KDM5B and KDM5C

M Schonfeld, J Averilla, S Gunewardena… - Hepatology …, 2022 - Wiley Online Library
Alcohol‐associated liver disease is a major cause of alcohol‐related mortality. However, the
mechanisms underlying disease progression are not fully understood. Recently we found …

2,3,7,8-Tetrachlorodibenzo-p-dioxin abolishes circadian regulation of hepatic metabolic activity in mice

KA Fader, R Nault, CM Doskey, RR Fling… - Scientific reports, 2019 - nature.com
Aryl hydrocarbon receptor (AhR) activation is reported to alter the hepatic expression of
circadian clock regulators, however the impact on clock-controlled metabolism has not been …

Endocrine disrupting chemicals and metabolic disorders in the liver: What if we also looked at the female side?

B Le Magueresse-Battistoni - Chemosphere, 2021 - Elsevier
Endocrine disrupting chemicals (EDCs) are linked to the worldwide epidemic incidence of
metabolic disorders and fatty liver diseases, which affects quality of life and represents a …

The environmental pollutant, polychlorinated biphenyl 126, alters liver function in a rodent model of alcohol‐associated liver disease

TC Gripshover, B Wahlang, KZ Head… - Alcohol: Clinical and …, 2023 - Wiley Online Library
Background The prevalence of alcohol‐associated liver disease (ALD), a subtype of fatty
liver disease (FLD), continues to rise. ALD is a major cause of preventable death …

[HTML][HTML] The aryl hydrocarbon receptor as a model PAS sensor

E Vazquez-Rivera, BL Rojas, JC Parrott, AL Shen… - Toxicology Reports, 2022 - Elsevier
Abstract Proteins containing PER-ARNT-SIM (PAS) domains are commonly associated with
environmental adaptation in a variety of organisms. The PAS domain is found in proteins …