Abstract Interferon Regulatory Factors (IRFs), a family of transcription factors, profoundly
influence the immune system, impacting both physiological and pathological processes …

Rheumatoid arthritis (RA) is a destructive inflammatory autoimmune disease that causes
pain and disability. Many of the currently available drugs for treating RA patients are aimed …

Abstract Short Linear Motifs (SLiMs) are the smallest structural and functional components of
modular eukaryotic proteins. They are also the most abundant, especially when considering …

Ubiquitination is essential for the proteasomal turnover of IRF3, the central factor mediating
the antiviral innate immune response. However, the spatiotemporal regulation of IRF3 …

Circular RNAs (circRNAs) as novel regulatory molecules have been recognized in diverse
species, including viruses. The virus-derived circRNAs play various roles in the host …

The interferon pathway is the first line of defense in viral infection in all mammals, and its
induction stimulates broad expression of interferon-stimulated genes (ISGs). In mice and …

The innate immune system is the first line of the host's defense, and studying the
mechanisms of the negative regulation of interferon (IFN) signaling is important for …

Many viruses, including foot-and-mouth disease virus (FMDV), can promote the degradation
of host proteins through macroautophagy/autophagy, thereby promoting viral replication …

Abstract Cyprinid herpesvirus type 3 (CyHV-3), also called Koi herpesvirus (KHV), which
leads to mass cyprinid mortality and enormous economic losses. To establish an infection …

SARS-CoV-2 has been a pandemic threat to human health and the worldwide economy, but
efficient treatments are still lacking. Type I and III interferons are essential for controlling viral …