The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential

GW Zamponi, J Striessnig, A Koschak… - Pharmacological …, 2015 - ASPET
Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond

AC Dolphin - Nature Reviews Neuroscience, 2012 - nature.com
The voltage-gated calcium channel α2δ and β subunits are traditionally considered to be
auxiliary subunits that enhance channel trafficking, increase the expression of functional …

Gabapentin receptor α2δ-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis

C Eroglu, NJ Allen, MW Susman, NA O'Rourke… - Cell, 2009 - cell.com
Synapses are asymmetric cellular adhesions that are critical for nervous system
development and function, but the mechanisms that induce their formation are not well …

The calcium channel subunit Alpha2delta2 suppresses axon regeneration in the adult CNS

A Tedeschi, S Dupraz, CJ Laskowski, J Xue, T Ulas… - Neuron, 2016 - cell.com
Injuries to the adult CNS often result in permanent disabilities because neurons lose the
ability to regenerate their axon during development. Here, whole transcriptome sequencing …

The β Subunit of Voltage-Gated Ca2+ Channels

Z Buraei, J Yang - Physiological reviews, 2010 - journals.physiology.org
Calcium regulates a wide spectrum of physiological processes such as heartbeat, muscle
contraction, neuronal communication, hormone release, cell division, and gene …

A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene

GG Neely, A Hess, M Costigan, AC Keene, S Goulas… - Cell, 2010 - cell.com
Worldwide, acute, and chronic pain affects 20% of the adult population and represents an
enormous financial and emotional burden. Using genome-wide neuronal-specific RNAi …

[HTML][HTML] The α2δ subunits of voltage-gated calcium channels

AC Dolphin - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2013 - Elsevier
Voltage-gated calcium channels consist of the main pore-forming α1 subunit, together,
except in the case of the T-type channels, with β and α2δ and sometimes γ subunits, which …

Calcium channel diversity: multiple roles of calcium channel subunits

AC Dolphin - Current opinion in neurobiology, 2009 - Elsevier
Until recently we held the simple view that voltage-gated calcium channels consisted of an
α1 subunit, usually associated with auxiliary β subunits and α2δ subunits and that skeletal …

[HTML][HTML] Voltage-gated calcium channel α 2δ subunits: an assessment of proposed novel roles

AC Dolphin - F1000Research, 2018 - ncbi.nlm.nih.gov
Voltage-gated calcium (Ca V) channels are associated with β and α 2 δ auxiliary subunits.
This review will concentrate on the function of the α 2 δ protein family, which has four …

Pokes, sunburn, and hot sauce: Drosophila as an emerging model for the biology of nociception

SH Im, MJ Galko - Developmental Dynamics, 2012 - Wiley Online Library
The word “nociception” is derived from the Latin “nocere,” which means “to harm.”
Nociception refers to the sensory perception of noxious stimuli that have the potential to …