Monkeypox: disease epidemiology, host immunity and clinical interventions
Monkeypox virus (MPXV), which causes disease in humans, has for many years been
restricted to the African continent, with only a handful of sporadic cases in other parts of the …
restricted to the African continent, with only a handful of sporadic cases in other parts of the …
Transporters and drug-drug interactions: important determinants of drug disposition and effects
Uptake and efflux transporters determine plasma and tissue concentrations of a broad
variety of drugs. They are localized in organs such as small intestine, liver, and kidney …
variety of drugs. They are localized in organs such as small intestine, liver, and kidney …
Antivirals with activity against mpox: a clinically oriented review
EA Siegrist, J Sassine - Clinical infectious diseases, 2023 - academic.oup.com
Mpox virus is an emergent human pathogen. While it is less lethal than smallpox, it can still
cause significant morbidity and mortality. In this review, we explore 3 antiviral agents with …
cause significant morbidity and mortality. In this review, we explore 3 antiviral agents with …
Acyclovir resistance in herpes simplex viruses: Prevalence and therapeutic alternatives
HH Schalkwijk, R Snoeck, G Andrei - Biochemical Pharmacology, 2022 - Elsevier
Herpes simplex viruses (HSV), the causative agents of recurrent orofacial and anogenital
infections, can cause significant morbidity and mortality in both immunocompetent and …
infections, can cause significant morbidity and mortality in both immunocompetent and …
Use of In Vitro and In Vivo Data to Estimate the Likelihood of Metabolic Pharmacokinetic Interactions
RJ Bertz, GR Granneman - Clinical pharmacokinetics, 1997 - Springer
This article reviews the information available to assist pharmacokineticists in the prediction
of metabolic drug interactions. Significant advances in this area have been made in the last …
of metabolic drug interactions. Significant advances in this area have been made in the last …
Drug-induced acute kidney injury
M Schetz, J Dasta, S Goldstein… - Current opinion in critical …, 2005 - journals.lww.com
The main mechanisms of nephrotoxicity are vasoconstriction, altered intraglomerular
hemodynamics, tubular cell toxicity, interstitial nephritis, crystal deposition, thrombotic …
hemodynamics, tubular cell toxicity, interstitial nephritis, crystal deposition, thrombotic …
Clinical potential of the acyclic nucleoside phosphonates cidofovir, adefovir, and tenofovir in treatment of DNA virus and retrovirus infections
E De Clercq - Clinical microbiology reviews, 2003 - Am Soc Microbiol
The acyclic nucleoside phosphonates HPMPC (cidofovir), PMEA (adefovir), and PMPA
(tenofovir) have proved to be effective in vitro (cell culture systems) and in vivo (animal …
(tenofovir) have proved to be effective in vitro (cell culture systems) and in vivo (animal …
Antiviral therapies for herpesviruses: current agents and new directions
CL Poole, SH James - Clinical therapeutics, 2018 - Elsevier
Purpose The objective of this review was to summarize the recent literature describing the
current burden of disease due to herpesviruses in the antiviral and transplant era; describe …
current burden of disease due to herpesviruses in the antiviral and transplant era; describe …
Quantitation of cytomegalovirus: methodologic aspects and clinical applications
Cytomegalovirus (CMV) is an important pathogen in transplant recipients and human
immunodeficiency virus (HIV)-infected individuals. Major progress has been made in …
immunodeficiency virus (HIV)-infected individuals. Major progress has been made in …
Transporter-mediated drug-drug interactions and their significance
X Liu - Drug Transporters in Drug Disposition, Effects and …, 2019 - Springer
Drug transporters are considered to be determinants of drug disposition and effects/toxicities
by affecting the absorption, distribution, and excretion of drugs. Drug transporters are …
by affecting the absorption, distribution, and excretion of drugs. Drug transporters are …