Venoms of heteropteran insects: a treasure trove of diverse pharmacological toolkits
The piercing-sucking mouthparts of the true bugs (Insecta: Hemiptera: Heteroptera) have
allowed diversification from a plant-feeding ancestor into a wide range of trophic strategies …
allowed diversification from a plant-feeding ancestor into a wide range of trophic strategies …
Functional divergence of heme-thiolate proteins: a classification based on spectroscopic attributes
1. INTRODUCTION Heme proteins are among the most versatile players in the biological
milieu; their functions range widely and include electron transfer, catalysis, and small …
milieu; their functions range widely and include electron transfer, catalysis, and small …
Repurposing a Nitric Oxide Transport Hemoprotein Nitrophorin 2 for Olefin Cyclopropanation
A growing number of heme proteins have recently been repurposed for catalyzing
abiological carbene transfer reactions. Herein, we rationally designed an engineered variant …
abiological carbene transfer reactions. Herein, we rationally designed an engineered variant …
Mycobacterial and human nitrobindins: Structure and function
G De Simone, A di Masi, GM Vita… - Antioxidants & Redox …, 2020 - liebertpub.com
Aims: Nitrobindins (Nbs) are evolutionary conserved all-β-barrel heme-proteins displaying a
highly solvent-exposed heme-Fe (III) atom. The physiological role (s) of Nbs is almost …
highly solvent-exposed heme-Fe (III) atom. The physiological role (s) of Nbs is almost …
Chemical Synthesis of the 20 kDa Heme Protein Nitrophorin 4 by α‐Ketoacid‐Hydroxylamine (KAHA) Ligation
C He, SS Kulkarni, F Thuaud… - Angewandte Chemie …, 2015 - Wiley Online Library
The chemical synthesis of the 184‐residue ferric heme‐binding protein nitrophorin 4 was
accomplished by sequential couplings of five unprotected peptide segments using α …
accomplished by sequential couplings of five unprotected peptide segments using α …
Insertion of unnatural metal ligand in the heme pocket of nitrophorin through protein semi-synthesis: Toward biomimicking binuclear active sites
Y Chen, Y Zhou, C He - Chinese Chemical Letters, 2023 - Elsevier
Herein, we report a semi-synthetic strategy affording a nitrophorin 2 (NP2) variant with a N,
N′-bis (2-pyridylmethyl) amine (Dpa) ligand as sidechain selectively installed at position …
N′-bis (2-pyridylmethyl) amine (Dpa) ligand as sidechain selectively installed at position …
Redox-dependent ligand switching in a sensory heme-binding GAF domain of the cyanobacterium nostoc sp. PCC7120
The genome of the cyanobacterium Nostoc sp. PCC7120 carries three genes (all4978,
all7016, and alr7522) encoding putative heme-binding GAF (cGMP-specific …
all7016, and alr7522) encoding putative heme-binding GAF (cGMP-specific …
Autoinduction, purification, and characterization of soluble α-globin chains of crocodile (Crocodylus siamensis) hemoglobin in Escherichia coli
We have established a method to express soluble heme-bound recombinant crocodile
(Crocodylus siamensis) α-globin chain holo-protein in bacteria (Escherichia coli) using an …
(Crocodylus siamensis) α-globin chain holo-protein in bacteria (Escherichia coli) using an …
Structural analysis of Cytochrome P450 BM3 mutant M11 in complex with dithiothreitol
K Frydenvang, MCA Verkade-Vreeker, F Dohmen… - Plos one, 2019 - journals.plos.org
The bacterial Cytochrome P450 (CYP) BM3 (CYP102A1) is one of the most active CYP
isoforms. BM3 mutants can serve as a model for human drug-metabolizing CYPs and/or as …
isoforms. BM3 mutants can serve as a model for human drug-metabolizing CYPs and/or as …
[PDF][PDF] Клинико-патогенетическое значение гомоцистеина при геморрагической лихорадке с почечным синдромом
ГР Латыпова - 2020 - bashgmu.ru
Актуальность темы исследования. Геморрагическая лихорадка с почечным синдромом
(ГЛПС)–острый вирусный природно-очаговый зооноз, который проявляется в виде …
(ГЛПС)–острый вирусный природно-очаговый зооноз, который проявляется в виде …