Palmitic acid: physiological role, metabolism and nutritional implications

G Carta, E Murru, S Banni, C Manca - Frontiers in physiology, 2017 - frontiersin.org
Palmitic acid (PA) has been for long time negatively depicted for its putative detrimental
health effects, shadowing its multiple crucial physiological activities. PA is the most common …

[HTML][HTML] The endocannabinoid system and its modulation by phytocannabinoids

V Di Marzo, F Piscitelli - Neurotherapeutics, 2015 - Elsevier
The endocannabinoid system is currently defined as the ensemble of the two 7-
transmembrane-domain and G protein-coupled receptors for Δ 9-tetrahydrocannabinol (but …

Endocannabinoids and endocannabinoid-related mediators: Targets, metabolism and role in neurological disorders

FA Iannotti, V Di Marzo, S Petrosino - Progress in lipid research, 2016 - Elsevier
The endocannabinoid system (ECS) is composed of two G protein-coupled receptors
(GPCRs), the cannabinoid CB1 and CB2 receptors, and the two main endogenous lipid …

The pharmacology of palmitoylethanolamide and first data on the therapeutic efficacy of some of its new formulations

S Petrosino, V Di Marzo - British journal of pharmacology, 2017 - Wiley Online Library
Palmitoylethanolamide (PEA) has emerged as a potential nutraceutical, because this
compound is naturally produced in many plant and animal food sources, as well as in cells …

Palmitoylethanolamide: a natural compound for health management

P Clayton, M Hill, N Bogoda, S Subah… - International journal of …, 2021 - mdpi.com
All nations which have undergone a nutrition transition have experienced increased
frequency and falling latency of chronic degenerative diseases, which are largely driven by …

[HTML][HTML] Cannabinoids as therapeutic agents in cancer: current status and future implications

B Chakravarti, J Ravi, RK Ganju - Oncotarget, 2014 - ncbi.nlm.nih.gov
The pharmacological importance of cannabinoids has been in study for several years.
Cannabinoids comprise of (a) the active compounds of the Cannabis sativa plant,(b) …

The basal pharmacology of palmitoylethanolamide

L Rankin, CJ Fowler - International Journal of Molecular Sciences, 2020 - mdpi.com
Palmitoylethanolamide (PEA, N-hexadecanoylethanolamide) is an endogenous compound
belonging to the family of N-acylethanolamines. PEA has anti-inflammatory and analgesic …

The endocannabinoid system and PPARs: Focus on their signalling crosstalk, action and transcriptional regulation

FA Iannotti, RM Vitale - Cells, 2021 - mdpi.com
Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear receptors
including PPARα, PPARγ, and PPARβ/δ, acting as transcription factors to regulate the …

Beyond THC and endocannabinoids

P Pacher, NM Kogan… - Annual review of …, 2020 - annualreviews.org
Research in the cannabinoid field, namely on phytocannabinoids, the endogenous
cannabinoids anandamide and 2-arachidonoyl glycerol and their metabolizing and synthetic …

The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities

T Bíró, BI Tóth, G Haskó, R Paus, P Pacher - Trends in pharmacological …, 2009 - cell.com
The newly discovered endocannabinoid system (ECS; comprising the endogenous lipid
mediators endocannabinoids present in virtually all tissues, their G-protein-coupled …