A decade of intensive investigation of coactivators and corepressors required for regulated
actions of DNA-binding transcription factors has revealed a network of sequentially …

Nuclear receptors regulate many biologically important processes in development and
homeostasis by their bimodal function as repressors and activators of gene transcription. A …

The most aggressive B cell lymphomas frequently manifest extranodal distribution and carry
somatic mutations in the poorly characterized gene TBL1XR1. Here, we show that TBL1XR1 …

Nr2e3 is an orphan nuclear receptor expressed specifically by retinal photoreceptor cells.
Mutations in Nr2e3 result in syndromes characterized by excess blue cones and loss of …

Androgen receptor (AR), a steroid hormone receptor, is critical for prostate cancer growth.
However, activation of AR by androgens can also lead to growth suppression and …

Eukaryotic transcriptional repressors function by recruiting large coregulatory complexes
that target histone deacetylase enzymes to gene promoters and enhancers. Transcriptional …

DNA methylation, one of the most well-studied epigenetic modifications, is involved in a
wide spectrum of biological processes. Epigenetic mechanisms control cellular morphology …

The current review focuses on the molecular mechanisms and developmental roles of
thyroid hormone receptors (TRs) in gene regulation and metamorphosis in Xenopus laevis …

Publisher Summary Amphibians exhibit considerable diversity in behavioral, physiological,
and life history strategies. They are geographically widespread, occupying a diverse range …

In multicellular organisms, development is based in part on the integration of communication
systems. Two neuroendocrine axes, the hypothalamic–pituitary–thyroid and the …