Osteoporosis is the most prevalent metabolic bone disease that affects half the women in the
sixth and seventh decade of life. Osteoporosis is characterized by uncoupled bone …

The regulation of linear growth by nutritional and inflammatory influences is examined in
terms of growth-plate endochondral ossification, in order to better understand stunted growth …

Osteoblasts, the bone-forming cells of the remodeling unit, are essential for growth and
maintenance of the skeleton. Clinical disorders of substrate availability (eg, diabetes …

The adult human skeleton is a multifunctional organ undergoing continuous remodeling.
Homeostasis of bone mass in a healthy adult requires an exquisite balance between bone …

Bone-related diseases are major contributors to morbidity and mortality in elderly people
and the current treatments result in insufficient healing and several complications. One of the …

The Wnt signalling pathway is one of the central signalling pathways in bone development,
homeostasis and regulation of bone mineral density. It consists of numerous Wnt ligands …

Growth faltering under 5 years of age is unacceptably high worldwide, and even more
children, while not stunted, fail to reach their growth potential. The time between conception …

The mammalian/mechanistic target of rapamycin (mTOR) is a serine/threonine protein
kinase that integrates inputs from nutrients and growth factors to control many fundamental …

Communication between osteoblasts and endothelial cells (ECs) is essential for bone
turnover, but the molecular mechanisms of such communication are not well defined. Here …

Age-induced osteoporosis is a global problem. Essential amino acids (EAAs) work as an
energy source and a molecular pathway modulator in bone, but their functions have not …