Muscarinic receptors in the mammalian heart

S Dhein, CJ Van Koppen, OE Brodde - Pharmacological research, 2001 - Elsevier
In the mammalian heart, cardiac function is under the control of the sympathetic and
parasympathetic nervous system. All regions of the mammalian heart are innervated by …

The Roles of Cardiovascular H2-Histamine Receptors Under Normal and Pathophysiological Conditions

J Neumann, U Kirchhefer, S Dhein… - Frontiers in …, 2021 - frontiersin.org
This review addresses pharmacological, structural and functional relationships among H2-
histamine receptors and H1-histamine receptors in the mammalian heart. The role of both …

Regulation of phospholamban and troponin-I phosphorylation in the intact rat cardiomyocytes by adrenergic and cholinergic stimuli: roles of cyclic nucleotides …

PV Sulakhe, XT Vo - Signal Transduction Mechanisms, 1995 - Springer
Protein phosphorylation was investigated in [32 P]-labeled cardiomyocytes isolated from
adult rat heart ventricles. The β-adrenergic stimulation (by isoproterenol, ISO) increased the …

Characterization of stressed transgenic mice overexpressing H2-histamine receptors in the heart

U Gergs, U Kirchhefer, F Bergmann, B Künstler… - The Journal of …, 2020 - Elsevier
We studied transgenic mice with cardiac-specific overexpression of H 2-histamine receptors
(H 2-TG) by using the α-myosin heavy-chain promoter. We wanted to address whether this …

Cardiac protein phosphorylation: functional and pathophysiological correlates

ST Rapundalo - Cardiovascular research, 1998 - academic.oup.com
Protein phosphorylation acts a pivotal mechanism in regulating the contractile state of the
heart by modulating particular levels of autonomic control on cardiac force/length …

Amitriptyline functionally antagonizes cardiac H2 histamine receptors in transgenic mice and human atria

J Neumann, MB Binter, C Fehse, M Marušáková… - Naunyn-schmiedeberg's …, 2021 - Springer
We have previously shown that histamine (2-(1 H-imidazol-4-yl) ethanamine) exerted
concentration-dependent positive inotropic effects (PIE) or positive chronotropic effects …

Muscarinic regulation of the L-type calcium current in isolated cardiac myocytes

PF Méry, N Abi-Gerges, G Vandecasteele, J Jurevicius… - Life sciences, 1997 - Elsevier
MUSCARINIC REGULATION OF THE L-TYPE CALCIUM CURRENT IN ISOLATED CARDIAC
MYOCYTES Pierre-Franqois M&y, Najah Abi-Gerges, GrCg Page 1 Life Sciences, Vol. 60, Nos …

On the cardiac contractile, biochemical and electrophysiological effects of cantharidin, a phosphatase inhibitor.

J Neumann, S Herzig, P Boknik, M Apel… - The Journal of …, 1995 - jpet.aspetjournals.org
Cantharidin concentration dependently increased the force of contraction in isolated guinea
pig papillary muscles (1-100 microM). The positive inotropic effect is accompanied by a …

Pertussis toxin induces angiogenesis in brain microvascular endothelial cells

C Lu, S Pelech, H Zhang, J Bond… - Journal of …, 2008 - Wiley Online Library
Pertussis toxin (PTX) is an ancillary adjuvant used to elicit experimental allergic
encephalomyelitis (EAE), the principal autoimmune model of multiple sclerosis. One …

Pertussis toxin sensitive and insensitive effects of adenosine and carbachol in murine atria overexpressing A1‐adenosine receptors

J Neumann, P Boknik, GP Matherne… - British journal of …, 2003 - Wiley Online Library
It was investigated how A1‐adenosine receptor overexpression alters the effects of
carbachol on force of contraction and beating rate in isolated murine atria. Moreover, the …