Human pluripotent stem cell-derived cardiomyocytes (hPS-CM) may offer a number of
advantages over previous cardiac models, however, questions of their immaturity complicate …

Biophysical signaling, an integral regulator of long-term cell behavior in both excitable and
non-excitable cell types, offers enormous potential for modulation of important cell functions …

Focal ectopic activity in cardiac tissue is a key factor in the initiation and perpetuation of
tachyarrhythmias. Because myofibroblasts as present in fibrotic remodeled myocardia and …

Metabolic pathologies mainly originate from adipose tissue (AT) dysfunctions. AT differences
are associated with fat-depot anatomic distribution in subcutaneous (SAT) and visceral …

Background Control of stem cell behavior is a crucial aspect of developmental biology and
regenerative medicine. While the functional role of electrophysiology in stem cell biology is …

Adult mesenchymal stem cells derived from adipose tissue (A-MSC) have the capacity to
differentiate in vitro into mesenchymal as well as endodermal and ectodermal cell lineages …

Hyperpolarization-activated, cyclic nucleotide–gated (HCN) channels are important
members of the voltage-gated pore loop channels family. They show unique features: they …

Human mesenchymal stem cells (hMSCs) are considered a promising cell source for
regenerative medicine, because they have the potential to differentiate into a variety of …

Bone marrow mesenchymal stem cells have been shown to transdifferentiate into
cardiomyocytes after 5-azacytidine treatment or co-culturing with rodent cardiomyocytes. We …

Background—Mesenchymal stem cells (MSCs) are bone marrow stromal cells that are in
phase 1 clinical studies of cellular cardiomyoplasty. However, the electrophysiological …