The response of immune cells in cardiac injury is divided into three continuous phases:
inflammation, proliferation and maturation. The kinetics of the inflammatory and proliferation …

Inflammation must be tightly regulated to both defend against pathogens and restore tissue
homeostasis. The resolution of inflammatory responses is a dynamic process orchestrated …

Cardiac macrophages represent a heterogeneous cell population with distinct origins,
dynamics, and functions. Recent studies have revealed that CC Chemokine Receptor 2 …

Macrophages are integral components of cardiac tissue and exert profound effects on the
healthy and diseased heart. Paradigm shifting studies using advanced molecular …

The heart contains a population of resident macrophages that markedly expands following
injury through recruitment of monocytes and through proliferation of macrophages. In …

Aims A robust inflammatory response to tissue injury is a necessary part of the repair
process but the deposition of scar tissue is a direct downstream consequence of this …

Advances in our understanding of cardiovascular development have provided a roadmap for
the directed differentiation of human pluripotent stem cells (hPSCs) to the major cell types …

Evolutionary developmental biology, or Evo-Devo for short, has become an established field
that, broadly speaking, seeks to understand how changes in development drive major …

Cardiac regeneration, that is, restoration of the original structure and function in a damaged
heart, differs from tissue repair, in which collagen deposition and scar formation often lead to …

Cardiac macrophages are essential mediators of cardiac development, tissue homeostasis,
and response to injury. Cell-intrinsic shifts in metabolism and availability of metabolites …