Mesenchymal stromal cell secretome: influencing therapeutic potential by cellular pre-conditioning

JR Ferreira, GQ Teixeira, SG Santos… - Frontiers in …, 2018 - frontiersin.org
Mesenchymal stromal cells (MSCs) are self-renewing, culture-expandable adult stem cells
that have been isolated from a variety of tissues, and possess multipotent differentiation …

Mesenchymal stem cells: immune evasive, not immune privileged

JA Ankrum, JF Ong, JM Karp - Nature biotechnology, 2014 - nature.com
The diverse immunomodulatory properties of mesenchymal stem/stromal cells (MSCs) may
be exploited for treatment of a multitude of inflammatory conditions. MSCs have long been …

Applying extracellular vesicles based therapeutics in clinical trials–an ISEV position paper

T Lener, M Gimona, L Aigner, V Börger… - Journal of …, 2015 - Taylor & Francis
Extracellular vesicles (EVs), such as exosomes and microvesicles, are released by different
cell types and participate in physiological and pathophysiological processes. EVs mediate …

[HTML][HTML] Homing and migration of mesenchymal stromal cells: how to improve the efficacy of cell therapy?

A De Becker, I Van Riet - World journal of stem cells, 2016 - ncbi.nlm.nih.gov
Mesenchymal stromal cells (MSCs) are currently being investigated for use in a wide variety
of clinical applications. For most of these applications, systemic delivery of the cells is …

Mesenchymal stromal cells and cutaneous wound healing: a comprehensive review of the background, role, and therapeutic potential

MS Hu, MR Borrelli, HP Lorenz… - Stem cells …, 2018 - Wiley Online Library
Cutaneous wound repair is a highly coordinated cascade of cellular responses to injury
which restores the epidermal integrity and its barrier functions. Even under optimal healing …

Mesenchymal stromal cell-derived extracellular vesicles protect the fetal brain after hypoxia-ischemia

DRMG Ophelders, TGAM Wolfs… - Stem cells …, 2016 - academic.oup.com
Preterm neonates are susceptible to perinatal hypoxic-ischemic brain injury, for which no
treatment is available. In a preclinical animal model of hypoxic-ischemic brain injury in ovine …

[HTML][HTML] Mesenchymal stem cells homing to improve bone healing

W Lin, L Xu, S Zwingenberger, E Gibon… - Journal of orthopaedic …, 2017 - Elsevier
Cell therapy continues to attract growing interest as a promising approach to treat a variety
of diseases. Mesenchymal stem cells (MSCs) have been one of the most intensely studied …

Dysfunction of mesenchymal stem cells isolated from metabolic syndrome and type 2 diabetic patients as result of oxidative stress and autophagy may limit their …

K Kornicka, J Houston, K Marycz - Stem cell reviews and reports, 2018 - Springer
Mesenchymal stem cells (MSC) have become a promising tool for therapeutic intervention.
Their unique features, including self-renewal, multipotency and immunomodulatory …

Concise review: clinical translation of wound healing therapies based on mesenchymal stem cells

WM Jackson, LJ Nesti, RS Tuan - Stem cells translational …, 2012 - academic.oup.com
There is enormous worldwide demand for therapies to promote the efficient resolution of
hard-to-heal wounds with minimal appearance of scarring. Recent in vitro studies with …

Mesenchymal stem cell therapy for attenuation of scar formation during wound healing

WM Jackson, LJ Nesti, RS Tuan - Stem cell research & therapy, 2012 - Springer
Scars are a consequence of cutaneous wound healing that can be both unsightly and
detrimental to the function of the tissue. Scar tissue is generated by excessive deposition of …