Huntington disease is devastating to patients and their families—with autosomal dominant
inheritance, onset typically in the prime of adult life, progressive course, and a combination …

Huntington's disease is an inherited neurodegenerative disease described 150 years ago
by George Huntington. The genetic defect was identified in 1993 to be an expanded CAG …

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …

Huntington disease (HD) can be seen as a model neurodegenerative disorder, in that it is
caused by a single genetic mutation and is amenable to predictive genetic testing, with …

Huntington's disease (HD) is an inherited neurodegenerative disorder caused by a
polyglutamine stretch in the huntingtin protein. Today, more than 15 years after the genetic …

Astrocytes are abundant within mature neural circuits and are involved in brain disorders.
Here, we summarize our current understanding of astrocytes and Huntington's disease (HD) …

Huntington's disease (HD), an incurable neurodegenerative disorder, has a complex
pathogenesis including protein aggregation and the dysregulation of neuronal transcription …

Cholesterol, an essential component of the brain, and its local metabolism are involved in
many neurodegenerative diseases. The blood-brain barrier is impermeable to cholesterol; …

Huntington's disease is an autosomal dominant neurodegenerative disease caused by
abnormal polyglutamine expansion in huntingtin (Exp-HTT) leading to degeneration of …

In contrast to their parent molecule cholesterol, two of its side-chain oxidized metabolites are
able to cross the blood–brain barrier. There is a concentration-driven flux of 24S …