Endocytosis is a critical step in the process by which many therapeutic nanomedicines reach
their intracellular targets. Our understanding of cellular uptake mechanisms has developed …

Endocytosis is a complex process whereby cell surface proteins, lipids and fluid from the
extracellular environment are packaged, sorted and internalized into cells. Endocytosis is …

A safe and controlled manipulation of endocytosis in vivo may have disruptive therapeutic
potential. Here, we demonstrate that the anti-emetic/anti-psychotic prochlorperazine can be …

Treatment of advanced (metastatic) non-small-cell lung cancer (NSCLC) is currently mainly
based on immunotherapy with antibodies against PD-1 or PD-L1, alone, or in combination …

Enhancing natural killer (NK) cell-based innate immunity has become a promising strategy
for immunotherapy against hard-to-cure solid cancers. Monoclonal antibody (mAb) therapy …

The natural history of adenoid cystic carcinoma (ACC) is relentless, defined by treatment
failure heralded by locoregional recurrence and distant metastatic disease. In this review …

Immune checkpoint molecules, especially PD-1 and its ligand PD-L1, act as a major
mechanism of cancer immune evasion. Although anti–PD-1/PD-L1 monotherapy increases …

Purpose: Statins are cholesterol-depleting drugs used to treat patients with
hypercholesterolemia. Preclinically, statins disrupt trafficking of receptors present at the cell …

Altered endocytosis and vesicular trafficking are major players during tumorigenesis. Flotillin
overexpression, a feature observed in many invasive tumors and identified as a marker of …

Long-Chain Non-Coding RNA (lncRNA) MT1JP Suppresses Biological Activities of Lung
Cancer by Regulating miRNA-423-3p/Bim Axis - PMC Back to Top Skip to main content NIH …