The ultimate goal of radiation oncology is to eradicate tumours without toxicity to non-
malignant tissues. FLASH radiotherapy, or the delivery of ultra-high dose rates of radiation …

Major strides have been made in the development of FLASH radiotherapy (FLASH RT) in
the last ten years, but there are still many obstacles to overcome for transfer to the clinic to …

Definition Flash radiotherapy (Flash-RT) is an innovative technique used in radiotherapy for
cancer treatment because it delivers an extremely high dose of radiation (> 40 Gy/s) to the …

Abstract Background/Purpose Investigating the antitumor effect and intratumor as well as
local immune response in breast cancer-bearing mice after MV X-ray ultra-high dose rate …

Ultra-high dose rate (UHDR) irradiation has been shown to have a sparing effect on healthy
tissue, an effect known as 'FLASH'. This effect has been studied across several radiation …

Purpose Although flash radiation therapy (FLASH‐RT) is a promising novel technique that
has the potential to achieve a better therapeutic ratio between tumor control and normal …

Ultra-high dose rate (UHDR) irradiation regimes have the potential to spare normal tissue
while keeping equivalent tumoricidal capacity than conventional dose rate radiotherapy …

DNA origami nanoframes with two parallel DNA sequences are used to evaluate the effect of
nucleoside substituents on radiation-induced DNA damage. Double strand breaks (DSB) of …

Background and purpose The impact of radiotherapy (RT) at ultra high vs conventional dose
rate (FLASH vs CONV) on the generation and repair of DNA double strand breaks (DSBs) is …

Purpose Normal tissue sparing has been shown in preclinical studies under the ultra-fast
dose rate condition, so-called FLASH radiotherapy. The preclinical and clinical FLASH …