Diversity of macrophages in lung homeostasis and diseases

F Hou, K Xiao, L Tang, L Xie - Frontiers in immunology, 2021 - frontiersin.org
Lung macrophages play important roles in the maintenance of homeostasis, pathogen
clearance and immune regulation. The different types of pulmonary macrophages and their …

The role of macrophages in the pathogenesis of ALI/ARDS

X Huang, H Xiu, S Zhang, G Zhang - Mediators of inflammation, 2018 - Wiley Online Library
Despite development in the understanding of the pathogenesis of acute lung injury
(ALI)/acute respiratory distress syndrome (ARDS), the underlying mechanism still needs to …

Flow cytometric analysis of macrophages and dendritic cell subsets in the mouse lung

AV Misharin, L Morales-Nebreda, GM Mutlu… - American journal of …, 2013 - atsjournals.org
The lung hosts multiple populations of macrophages and dendritic cells, which play a crucial
role in lung pathology. The accurate identification and enumeration of these subsets are …

Diverse macrophage populations mediate acute lung inflammation and resolution

NR Aggarwal, LS King… - American Journal of …, 2014 - journals.physiology.org
Acute respiratory distress syndrome (ARDS) is a devastating disease with distinct
pathological stages. Fundamental to ARDS is the acute onset of lung inflammation as a part …

Role of macrophages in acute lung injury and chronic fibrosis induced by pulmonary toxicants

DL Laskin, R Malaviya, JD Laskin - Toxicological Sciences, 2019 - academic.oup.com
A diverse group of toxicants has been identified that cause injury to the lung including gases
(eg, ozone, chlorine), particulates/aerosols (eg, diesel exhaust, fly ash, other combustion …

[HTML][HTML] The therapeutic potential of galectin-3 inhibition in fibrotic disease

RJ Slack, R Mills, AC Mackinnon - … Journal of Biochemistry & Cell Biology, 2021 - Elsevier
Galectin-3 is a beta-galactoside-binding mammalian lectin and part of the 15 member
galectin family that are evolutionarily highly conserved. It is the only chimeric protein with a …

[HTML][HTML] Pinostrobin ameliorates lipopolysaccharide (LPS)-induced inflammation and endotoxemia by inhibiting LPS binding to the TLR4/MD2 complex

AMGK Athapaththu, KT Lee, MHD Kavinda… - Biomedicine & …, 2022 - Elsevier
Pinostrobin is a natural flavonoid with valuable pharmacological properties, including anti-
cancer, anti-viral, and anti-oxidant activities. However, the anti-inflammatory effects of …

Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing

M Sorkin, AK Huber, C Hwang, WF Carson IV… - Nature …, 2020 - nature.com
Heterotopic ossification (HO) is an aberrant regenerative process with ectopic bone
induction in response to musculoskeletal trauma, in which mesenchymal stem cells (MSC) …

Vascular neutrophilic inflammation and immunothrombosis distinguish severe COVID‐19 from influenza pneumonia

L Nicolai, A Leunig, S Brambs, R Kaiser… - … of Thrombosis and …, 2021 - Wiley Online Library
Objective Infection with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)
can lead to severe pneumonia, but also thrombotic complications and non‐pulmonary organ …

Role of alveolar macrophages in chronic obstructive pulmonary disease

R Vlahos, S Bozinovski - Frontiers in immunology, 2014 - frontiersin.org
Alveolar macrophages (AMs) represent a unique leukocyte population that responds to
airborne irritants and microbes. This distinct microenvironment coordinates the maturation of …