RNA modifications and RNA metabolism in neurological disease pathogenesis
B Chatterjee, CKJ Shen, P Majumder - International journal of molecular …, 2021 - mdpi.com
The intrinsic cellular heterogeneity and molecular complexity of the mammalian nervous
system relies substantially on the dynamic nature and spatiotemporal patterning of gene …
system relies substantially on the dynamic nature and spatiotemporal patterning of gene …
Temperature-dependent RNA editing in octopus extensively recodes the neural proteome
In poikilotherms, temperature changes challenge the integration of physiological function.
Within the complex nervous systems of the behaviorally sophisticated coleoid cephalopods …
Within the complex nervous systems of the behaviorally sophisticated coleoid cephalopods …
Investigating RNA editing in deep transcriptome datasets with REDItools and REDIportal
RNA editing is a widespread post-transcriptional mechanism able to modify transcripts
through insertions/deletions or base substitutions. It is prominent in mammals, in which …
through insertions/deletions or base substitutions. It is prominent in mammals, in which …
Autorecoding A-to-I RNA editing sites in the Adar gene underwent compensatory gains and losses in major insect clades
As one of the most prevalent RNA modifications in animals, adenosine-to-inosine (A-to-I)
RNA editing facilitates the environmental adaptation of organisms by diversifying the …
RNA editing facilitates the environmental adaptation of organisms by diversifying the …
A full repertoire of Hemiptera genomes reveals a multi-step evolutionary trajectory of auto-RNA editing site in insect Adar gene
L Ma, C Zheng, S Xu, Y Xu, F Song, L Tian, W Cai… - RNA biology, 2023 - Taylor & Francis
ABSTRACT Adenosine-to-inosine (A-to-I) RNA editing, mediated by metazoan ADAR
enzymes, is a prevalent post-transcriptional modification that diversifies the proteome and …
enzymes, is a prevalent post-transcriptional modification that diversifies the proteome and …
Cellular and genetic drivers of RNA editing variation in the human brain
Posttranscriptional adenosine-to-inosine modifications amplify the functionality of RNA
molecules in the brain, yet the cellular and genetic regulation of RNA editing is poorly …
molecules in the brain, yet the cellular and genetic regulation of RNA editing is poorly …
The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer's …
Background RNA editing at the Q/R site of GluA2 occurs with~ 99% efficiency in the healthy
brain, so that the majority of AMPARs contain GluA2 (R) instead of the exonically encoded …
brain, so that the majority of AMPARs contain GluA2 (R) instead of the exonically encoded …
Adar RNA editing-dependent and -independent effects are required for brain and innate immune functions in Drosophila
P Deng, A Khan, D Jacobson, N Sambrani… - Nature …, 2020 - nature.com
ADAR RNA editing enzymes are high-affinity dsRNA-binding proteins that deaminate
adenosines to inosines in pre-mRNA hairpins and also exert editing-independent effects …
adenosines to inosines in pre-mRNA hairpins and also exert editing-independent effects …
Genome-wide analysis on driver and passenger RNA editing sites suggests an underestimation of adaptive signals in insects
Y Zhang, Y Duan - Genes, 2023 - mdpi.com
Adenosine-to-inosine (A-to-I) RNA editing leads to a similar effect to A-to-G mutations. RNA
editing provides a temporo-spatial flexibility for organisms. Nonsynonymous (Nonsyn) RNA …
editing provides a temporo-spatial flexibility for organisms. Nonsynonymous (Nonsyn) RNA …