Prior to the genome-wide association era, candidate gene studies were a major approach in
schizophrenia genetics. In this invited review, we consider the current status of 25 historical …

Herein, we review the multifaceted roles of proline in cell biology. This peculiar cyclic imino
acid is:(i) A main precursor of extracellular collagens (the most abundant human proteins) …

This review critically summarizes the neuropathology and genetics of schizophrenia, the
relationship between them, and speculates on their functional convergence. The …

1. After 50 years of antipsychotic drug development focused on the dopamine D2 receptor,
schizophrenia remains a chronic, disabling disorder for most affected individuals. 2. Studies …

Schizophrenia is a neurodevelopmental disorder that affects up to 1% of the general
population. Various genes show associations with schizophrenia and a very weak nominal …

Abstract The National Institute of Mental Health (NIMH) convened a meeting in September
2005 to review tobacco use and dependence and smoking cessation among those with …

Neurodevelopmental models of schizophrenia that identify longitudinal precursors of illness
have been of great heuristic importance focusing most etiologic research over the past two …

Recent studies are beginning to paint a clear and consistent picture of the impairments in
psychological and cognitive competencies that are associated with microdeletions in …

Bipolar disorder (BPD) and schizophrenia (SZ) are severe psychiatric illnesses with a
combined prevalence of 4%. A disturbance of energy metabolism is frequently observed in …

Recurrent copy number variations (CNVs) of human 16p11. 2 have been associated with a
variety of developmental/neurocognitive syndromes. In particular, deletion of 16p11. 2 is …