Avian cold adaptation is hallmarked by innovative strategies of both heat conservation and
thermogenesis. While minimizing heat loss can reduce the thermogenic demands of body …

Duchenne muscular dystrophy (DMD) is caused by the absence of the dystrophin protein
and a properly functioning dystrophin-associated protein complex (DAPC) in muscle cells …

Skeletal muscle contraction relies on both high-fidelity calcium (Ca2+) signals and robust
capacity for adenosine triphosphate (ATP) generation. Ca2+ release units (CRUs) are highly …

Abstract Store-operated Ca 2+ entry (SOCE) is a Ca 2+ entry mechanism activated by
depletion of intracellular Ca 2+ stores. In skeletal muscle, SOCE is mediated by an …

Cardiac, skeletal, and smooth muscle cells shared the common feature of contraction in
response to different stimuli. Agonist-induced muscle's contraction is triggered by a cytosolic …

The excitation–contraction coupling (ECC) in skeletal muscle refers to the Ca2+-mediated
link between the membrane excitation and the mechanical contraction. The initiation and …

Store-operated Ca2+ entry (SOCE) is a ubiquitous Ca2+ influx mechanism triggered by
depletion of Ca2+ stores from the endoplasmic/sarcoplasmic reticulum (ER/SR). We recently …

Calsequestrin (CASQ) was discovered in rabbit skeletal muscle tissues in 1971 and has
been considered simply a passive Ca2+-buffering protein in the sarcoplasmic reticulum (SR) …

Duchenne muscular dystrophy (DMD), an X-linked disorder caused by loss-of-function
mutations in the dystrophin gene, is characterized by progressive muscle degeneration and …

Sarcalumenin (SAR) is a luminal Ca2+ buffer protein with high capacity but low affinity for
calcium binding found predominantly in the longitudinal sarcoplasmic reticulum (SR) of fast …