The androgen receptor (AR), a member of the nuclear steroid hormone receptor family of
transcription factors, plays a crucial role not only in the development of the male phenotype …

The contribution of three-dimensional genome organization to physiological ageing is not
well known. Here we show that large-scale chromatin reorganization distinguishes young …

The development and function of the immune system are controlled by temporospatial gene
expression programs, which are regulated by cis-regulatory elements, chromatin structure …

Super-enhancers are a category of active super-enhancers densely occupied by
transcription factors and chromatin regulators, controlling the expression of disease-related …

Topologically associated domains (TADs) restrict promoter-enhancer interactions, thereby
maintaining the spatiotemporal pattern of gene activity. However, rearrangements of the …

Topologically associating domains (TADs) are chromatin domains in the eukaryotic genome.
TADs often comprise several sub‐TADs. The boundaries of TADs and sub‐TADs are …

The pair of transcription factors Bcl6-Blimp1 is well-known for follicular T helper (Tfh) cell fate
determination, however, the mechanism (s) for Bcl6-independent regulation of CXCR5 …

Chromatin structure varies dramatically among single cells, yet the specific motifs
underpinning this organization remain poorly understood. Using imaging-based spatial …

La spermatogenèse est le processus de différenciation des cellules germinales mâles en
spermatozoïdes. Elle est divisée en trois phases-la prolifération des spermatogonies, la …