Following axotomy, the activation of multiple intracellular signaling cascades causes the
expression of a cocktail of regeneration-associated transcription factors which interact with …

Originally implicated in the regulation of survival, proliferation and differentiation of
haematopoietic cells, the JAK-STAT pathway has also been linked to developmental …

Interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α) are key anti-and pro-inflammatory
mediators elicited during the host immune response to Mycobacterium tuberculosis (Mtb) …

Interleukin-6-type cytokines play important roles in the communication between cells of
multicellular organisms. They are involved in the regulation of complex cellular processes …

Inflammation is a beneficial mechanism that is usually triggered by injury or infection and is
designed to return the body to homeostasis. However, uncontrolled or sustained …

Due to the intrinsic stochasticity, the signaling dynamics in a clonal population of cells
exhibit cell-to-cell variability at the single-cell level, which is distinct from the population …

Inflammatory bowel disease (IBD) is a chronic and relapsing disease with multiple
underlying influences and notable heterogeneity among its clinical and response‐to …

IL-6 signaling plays an important role in inflammatory processes in the body. While a
number of models for IL-6 signaling are available, the parameters associated with these …

In this study, we have developed a multiscale systems model of interleukin (IL)‐6–mediated
immune regulation in Crohn's disease, by integrating intracellular signaling with organ‐level …

A mathematical model is developed and validated for a multistep binding process between
cholera toxin subunit B (CTB) and GD1b receptors that precedes cholera infection. To study …