Amino acids are necessary for all living cells and organisms. Specialized transporters
mediate the transfer of amino acids across plasma membranes. Malfunction of these …

Abstract l-Arginine is an essential amino acid for birds and young mammals, and it is a
conditionally essential amino acid for adult mammals, as it is important in situations in which …

CORONAVIRUSES, like many animal viruses, are characterized by a restricted host range
and tissue tropism1. Transmissible gastroenteritis virus (TGEV), a major pathogen causing a …

Palacı́n, Manuel, Raúl Estévez, Joan Bertran, and Antonio Zorzano. Molecular Biology of
Mammalian Plasma Membrane Amino Acid Transporters. Physiol. Rev. 78: 969–1054, 1998 …

Emerging evidence indicates that the Achilles' heel of cancer immunotherapies is often the
complex interplay of tumor‐derived factors and deviant host properties, which involve a wide …

As the applications of metabolic imaging are expanding, radiolabeled amino acids may gain
increased clinical interest. This review first describes the basic aspects of amino acid …

The blood-brain barrier (BBB) is formed by epithelial-like high resistance tight junctions
within the endothelium of capillaries perfusing the vertebrate brain. Because of the presence …

A cDNA was isolated from mouse testis which encodes a Na+-dependent neutral amino acid
transporter. The encoded protein, designated ASCT2, showed amino acid sequence …

In most regions of the brain, the uptake of glutamate and other anionic excitatory amino
acids from the circulation is limited by the blood-brain barrier (BBB). In most animals, the …

While transport processes for amino acids and glucose have long been known to be
expressed in the luminal and abluminal membranes of the endothelium comprising the …