Cardiac MRI Endpoints in Myocardial Infarction Experimental and Clinical Trials: JACC Scientific Expert Panel

B Ibanez, AH Aletras, AE Arai, H Arheden, J Bax… - Journal of the American …, 2019 - jacc.org
After a reperfused myocardial infarction (MI), dynamic tissue changes occur (edema,
inflammation, microvascular obstruction, hemorrhage, cardiomyocyte necrosis, and …

Evolving therapies for myocardial ischemia/reperfusion injury

B Ibáñez, G Heusch, M Ovize, F Van de Werf - Journal of the American …, 2015 - jacc.org
The damage inflicted on the myocardium during acute myocardial infarction is the result of 2
processes: ischemia and subsequent reperfusion (ischemia/reperfusion injury). During the …

Myocardial ischemia-reperfusion injury: a neglected therapeutic target

DJ Hausenloy, DM Yellon - The Journal of clinical …, 2013 - Am Soc Clin Investig
Acute myocardial infarction (MI) is a major cause of death and disability worldwide. In
patients with MI, the treatment of choice for reducing acute myocardial ischemic injury and …

Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart

DJ Hausenloy, D Garcia-Dorado… - Cardiovascular …, 2017 - academic.oup.com
Ischaemic heart disease and the heart failure that often results, remain the leading causes of
death and disability in Europe and worldwide. As such, in order to prevent heart failure and …

Prevalence and significance of impaired microvascular tissue reperfusion despite macrovascular angiographic reperfusion (no-reflow)

FC Ng, L Churilov, N Yassi, TJ Kleinig, V Thijs, T Wu… - Neurology, 2022 - AAN Enterprises
Background and Objectives The relevance of impaired microvascular tissue-level
reperfusion despite complete upstream macrovascular angiographic reperfusion (no-reflow) …

Optimized treatment of ST-elevation myocardial infarction: the unmet need to target coronary microvascular obstruction as primary treatment goal to further improve …

G Niccoli, RA Montone, B Ibanez, H Thiele… - Circulation …, 2019 - Am Heart Assoc
Primary percutaneous coronary intervention is nowadays the preferred reperfusion strategy
for patients with acute ST-segment–elevation myocardial infarction, aiming at restoring …

Cell therapy for heart failure: a comprehensive overview of experimental and clinical studies, current challenges, and future directions

SK Sanganalmath, R Bolli - Circulation research, 2013 - Am Heart Assoc
Despite significant therapeutic advances, the prognosis of patients with heart failure (HF)
remains poor, and current therapeutic approaches are palliative in the sense that they do not …

Myocardial reperfusion injury: looking beyond primary PCI

GM Fröhlich, P Meier, SK White, DM Yellon… - European heart …, 2013 - academic.oup.com
Coronary heart disease (CHD) is the leading cause of death and disability in Europe. For
patients presenting with an acute ST-segment elevation myocardial infarction (STEMI) …

An improved MR imaging technique for the visualization of myocardial infarction

OP Simonetti, RJ Kim, DS Fieno, HB Hillenbrand, E Wu… - Radiology, 2001 - pubs.rsna.org
PURPOSE: To design a segmented inversion-recovery turbo fast low-angle shot
(turboFLASH) magnetic resonance (MR) imaging pulse sequence for the visualization of …

Postconditioning the human heart

P Staat, G Rioufol, C Piot, Y Cottin, TT Cung… - Circulation, 2005 - Am Heart Assoc
Background—In animal models, brief periods of ischemia performed just at the time of
reperfusion can reduce infarct size, a phenomenon called postconditioning. In this …