Placental DNA methylation in pregnancies complicated by maternal diabetes and/or obesity: State of the art and research gaps

L Hjort, B Novakovic, S Cvitic, R Saffery, P Damm… - Epigenetics, 2022 - Taylor & Francis
Maternal diabetes and/or obesity in pregnancy are undoubtedly associated with later
disease-risk in the offspring. The placenta, interposed between the mother and the foetus, is …

[PDF][PDF] Genetics of fat deposition.

G Camilleri, AK Kiani, KL Herbst… - European Review for …, 2021 - europeanreview.org
Adipose tissue distribution usually varies among men and women. In men, adipose tissue is
known to accumulate in the abdominal region surrounding the visceral organs (android fat …

[HTML][HTML] Maternal gestational diabetes influences DNA methylation in the serotonin system in the human placenta

JY Song, KE Lee, EJ Byeon, J Choi, SJ Kim, JE Shin - Life, 2022 - mdpi.com
The offspring of mothers with gestational diabetes mellitus (GDM) are at a higher risk for
metabolic dysregulation and neurodevelopmental impairment. Evidence suggests that …

Gestational diabetes mellitus: genetic factors, epigenetic alterations, and microbial composition

D Lizárraga, B Gómez-Gil, T García-Gasca… - Acta Diabetologica, 2024 - Springer
Gestational diabetes mellitus (GDM) is a common metabolic disorder, usually diagnosed
during the third trimester of pregnancy that usually disappears after delivery. In GDM, the …

[HTML][HTML] FTO gene polymorphisms at the crossroads of metabolic pathways of obesity and epigenetic influences

AM Popović, A Huđek Turković, K Žuna… - Food Technology and …, 2023 - hrcak.srce.hr
Sažetak In this review, we summarize the current state of knowledge on the fat mass and
obesity-associated (FTO) gene and its role in obesity. The FTO-encoded protein is involved …

[HTML][HTML] Inositols, Probiotics, and gestational Diabetes: clinical and epigenetic aspects

E Vitacolonna, M Masulli, L Palmisano, L Stuppia… - Nutrients, 2022 - mdpi.com
There is growing interest in the potential role of different stereoisomers of inositol or their
combination as well as probiotics supplementation in healthy glucose metabolism during …

Exploring the role of m6A modification in the great obstetrical syndromes

J Ning, J Yan, H Yang - The Journal of Maternal-Fetal & Neonatal …, 2023 - Taylor & Francis
Abstract Background N6-methyladenosine (m6A) is one of the predominant RNA epigenetic
modifications that modify RNAs reversibly and dynamically by “writers”(methyltransferase),“ …

[HTML][HTML] The obesogenic environment: Epigenetic modifications in placental melanocortin 4 receptor gene connected to gestational diabetes and smoking

M Franzago, A Porreca, M D'Ardes, M Di Nicola… - Frontiers in …, 2022 - frontiersin.org
Background Maternal metabolic insults as well as Gestational Diabetes Mellitus (GDM)
influence the fetal health and may affect 'offspring's susceptibility to chronic diseases via …

MiRNA-based “fitness score” to assess the individual response to diet, metabolism, and exercise

UDB Krammer, S Tschida, J Berner, S Lilja… - Journal of the …, 2022 - Taylor & Francis
Background Regular, especially sustained exercise plays an important role in the prevention
and treatment of multiple chronic diseases. Some of the underlying molecular and cellular …

Genomic analysis to screen potential genes and mutations in children with non-syndromic early onset severe obesity: a multicentre study in Turkey

A Akinci, A Kara, A Özgür, D Turkkahraman… - Molecular Biology …, 2022 - Springer
Background Obesity is a complex genetic-based pediatric disorder which triggers life-
threatening conditions. Therefore, the understanding the molecular mechanisms of obesity …