Advances of the small molecule drugs regulating fibroblast-like synovial proliferation for rheumatoid arthritis

Y Tong, X Li, Q Deng, J Shi, Y Feng… - Frontiers in Pharmacology, 2023 - frontiersin.org
Rheumatoid arthritis (RA) is a type of chronic autoimmune and inflammatory disease. In the
pathological process of RA, the alteration of fibroblast-like synoviocyte (FLS) and its related …

Rheumatoid arthritis molecular targets and their importance to flavonoid‐based therapy

AT Rufino, M Freitas, C Proença… - Medicinal Research …, 2024 - Wiley Online Library
Rheumatoid arthritis (RA) is a progressive, chronic, autoimmune, inflammatory, and systemic
condition that primarily affects the synovial joints and adjacent tissues, including bone …

Therapeutic potential of exosomal circRNA derived from synovial mesenchymal cells via targeting circEDIL3/miR-485-3p/PIAS3/STAT3/VEGF functional module in …

J Zhang, Y Zhang, Y Ma, L Luo, M Chu… - International Journal of …, 2021 - Taylor & Francis
Background Synovial inflammation and its associated activation of angiogenesis play critical
roles in rheumatoid arthritis (RA). Exosomes, as carriers of genetic information including …

Anthocyanins as Immunomodulatory Dietary Supplements: A Nutraceutical Perspective and Micro-/Nano-Strategies for Enhanced Bioavailability

TP Ijinu, LF De Lellis, S Shanmugarama… - Nutrients, 2023 - mdpi.com
Anthocyanins (ACNs) have attracted considerable attention for their potential to modulate
the immune system. Research has revealed their antioxidant and anti-inflammatory …

[HTML][HTML] 5-aminolevulinic acid-loaded dissolving microneedle array for photodynamic therapy of rheumatoid arthritis on rats

Y Li, L Zheng, W Cao, X Yang, Q Wang, X Gu… - Biomedicine & …, 2023 - Elsevier
Photodynamic therapy (PDT) is a noninvasive technique that can be used to treat
rheumatoid arthritis (RA) by irradiating photosensitizers with specific wavelengths of light to …

8-Shogaol inhibits rheumatoid arthritis through targeting TAK1

S Jo, S Samarpita, JS Lee, YJ Lee, JE Son… - Pharmacological …, 2022 - Elsevier
Rheumatoid arthritis (RA) is a chronic immune-mediated disorder, mainly characterized by
synovial inflammation and joint damage. If insufficiently treated, RA can lead to irreversible …

Phytochemicals targeting JAK/STAT pathway in the treatment of rheumatoid arthritis: Is there a future?

G Kour, R Choudhary, S Anjum, A Bhagat… - Biochemical …, 2022 - Elsevier
Rheumatoid arthritis (RA) is a chronic autoimmune disorder and the treatment involves the
use of traditional and biological disease modifying anti-rheumatic drugs (DMARDs). Recent …

Bavachinin ameliorates rheumatoid arthritis inflammation via PPARG/PI3K/AKT signaling pathway

H Deng, J Jiang, J Shu, M Huang, QL Zhang, LJ Wu… - Inflammation, 2023 - Springer
Bavachinin (BVC) is a natural small molecule from the Chinese herb Fructus Psoraleae. It
exhibits numerous pharmacological effects, including anti-cancer, anti-inflammation, anti …

Advanced biomarkers: therapeutic and diagnostic targets in urticaria

Y Zhang, H Zhang, S Du, S Yan, J Zeng - International archives of …, 2021 - karger.com
Urticaria is a type of skin disease characterized by rapid onset of hives (superficial dermis
edema, erythema, pruritus, or burning sensation). According to whether the natural course …

CCN proteins in the musculoskeletal system: current understanding and challenges in physiology and pathology

V Giusti, K Scotlandi - Journal of Cell Communication and …, 2021 - Wiley Online Library
The acronym for the CCN family was recently revised to represent “cellular communication
network”. These six, small, cysteine‐enriched and evolutionarily conserved proteins are …