The interaction between T cell and dendritic cells (DCs) that leads to T cell activation affects
the progression of the immune response including autoimmune diseases. Antigen …

Integrins dynamically equilibrate between three conformational states on cell surfaces. A
bent conformation has a closed headpiece. Two extended conformations contain either a …

The molecular interactions underlying regulation of the immune response take place in a
nanoscale gap between T cells and antigen-presenting cells, termed the immunological …

T cell activation and function require a structured engagement of antigen-presenting cells.
These cell contacts are characterized by two distinct dynamics in vivo: transient contacts …

Abstract The immunoregulatory enzyme indoleamine 2, 3-dioxygenase (IDO) is expressed
by a subset of murine plasmacytoid DCs (pDCs) in tumor-draining lymph nodes (TDLNs) …

The immunological synapse has been an area of very active scientific interest over the last
decade. Surprisingly, much about the synapse remains unknown or is controversial. Here …

T cell activation depends on extracellular ligation of the T cell receptor (TCR) by peptide–
MHC complexes in a synapse between the T cell and an antigen-presenting cell. The …

Signaling processes between various immune cells involve large-scale spatial
reorganization of receptors and signaling molecules within the cell-cell junction. These …

Costimulation is a concept that goes back to the early 1980s when Lafferty and others
hypothesized that cell surface and soluble molecules must exist that are essential for …

T cells express a somatically recombined antigen receptor (αβTCR) that is calibrated during
development to respond to changes in peptides displayed by major histocompatibility …