Background: The renin angiotensin aldosterone system (RAAS) plays a vital role in
regulating glucose metabolism and blood pressure, electrolyte and fluid homeostasis. The …

Type 2 diabetes mellitus (T2DM) is a non-autoimmune, complex, heterogeneous and
polygenic metabolic disease condition characterized by persistent elevated blood glucose …

OBJECTIVE: Diabetic nephropathy (DN) has become the leading cause of end-stage renal
disease, but the pathogenesis of this condition is not exactly understood. Several studies …

Introduction: The effect of angiotensin-converting enzyme (ACE) insertion/deletion (I/D)
polymorphism on risk of diabetic nephropathy (DN) is still conflicting. The present meta …

In this meta-analysis study, SNPs were investigated for their association with type 2 diabetes
(T2D) in both Arab and Caucasian ethnicities. A total of 55 SNPs were analyzed, of which 11 …

The angiotensin converting enzyme (ACE) I/D polymorphism has been one of the most
studied genetic systems. It comprises hundreds of reports and a myriad of disease …

Background: Genetic variations have been proposed to play a role in the susceptibility to
diabetic nephropathy. Objectives: To check for the association of genetic polymorphisms of …

Method: This study comprised of 600 subjects, which include patients with DN, T2D, and
healthy controls (HC). Polymerase chain reaction based genotyping of ACE I/D …

This study was designed to investigate whether V16A polymorphism of the manganese
superoxide dismutase (Mn-SOD) gene is associated with the development of type 2 …

BACKGROUND: Wide inter-ethnic allelic variations of the Angiotensin Converting Enzyme
(ACE) i nsertion-deletion (I/D) gene polymorphism were thought to be responsible for the …