Dysfunctional vascular endothelium as a driver of atherosclerosis: emerging insights into pathogenesis and treatment

SR Botts, JE Fish, KL Howe - Frontiers in pharmacology, 2021 - frontiersin.org
Atherosclerosis, the chronic accumulation of cholesterol-rich plaque within arteries, is
associated with a broad spectrum of cardiovascular diseases including myocardial …

Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?

JM Abais, M Xia, Y Zhang, KM Boini… - Antioxidants & redox …, 2015 - liebertpub.com
Significance: Inflammasomes are multiprotein complexes localized within the cytoplasm of
the cell that are responsible for the maturation of proinflammatory cytokines such as …

The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer's disease

M Saresella, F La Rosa, F Piancone, M Zoppis… - Molecular …, 2016 - Springer
Abstract Background Interleukin-1 beta (IL-1β) and its key regulator, the inflammasome, are
suspected to play a role in the neuroinflammation observed in Alzheimer's disease (AD); no …

NLRP 3 inflammasome expression and activation in human atherosclerosis

G Paramel Varghese, L Folkersen… - Journal of the …, 2016 - Am Heart Assoc
Background The NLR family, pyrin domain containing 3 (NLRP 3) inflammasome is an
interleukin (IL)‐1β and IL‐18 cytokine processing complex that is activated in inflammatory …

[HTML][HTML] Trimethylamine-N-oxide instigates NLRP3 inflammasome activation and endothelial dysfunction

KM Boini, T Hussain, PL Li, SS Koka - Cellular Physiology and …, 2018 - karger.com
Background/Aim: Plasma trimethylamine-N-oxide (TMAO), a product of intestinal microbial
metabolism of dietary phosphatidylcholine has been recently associated with …

The health advantage of a vegan diet: exploring the gut microbiota connection

M Glick-Bauer, MC Yeh - Nutrients, 2014 - mdpi.com
This review examines whether there is evidence that a strict vegan diet confers health
advantages beyond that of a vegetarian diet or overall healthy eating. Few studies include …

Novel insights into the NLRP 3 inflammasome in atherosclerosis

Y Jin, J Fu - Journal of the American Heart Association, 2019 - Am Heart Assoc
Atherosclerosis underlies the leading cause of death in industrialized countries. 1
Atherosclerosis is a maladaptive, nonresolving chronic inflammatory disease that occurs …

The NLRP3 inflammasome is involved in the pathogenesis of Parkinson's disease in rats

Z Mao, C Liu, S Ji, Q Yang, H Ye, H Han, Z Xue - Neurochemical research, 2017 - Springer
The etiology and pathogenesis of Parkinson's disease (PD) are complicated and have not
been fully elucidated, but an important association has been identified between …

Ogg1-Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents Atherosclerosis

G Tumurkhuu, K Shimada, J Dagvadorj… - Circulation …, 2016 - Am Heart Assoc
Rationale: Activation of NLRP3 (nucleotide-binding domain and leucine-rich repeat pyrin
domain containing 3) inflammasome-mediating interleukin (IL)-1β secretion has emerged as …

Attenuation of 7-ketocholesterol-and 7β-hydroxycholesterol-induced oxiapoptophagy by nutrients, synthetic molecules and oils: Potential for the prevention of age …

T Nury, A Yammine, I Ghzaiel, K Sassi, A Zarrouk… - Ageing research …, 2021 - Elsevier
Age-related diseases for which there are no effective treatments include cardiovascular
diseases; neurodegenerative diseases such as Alzheimer's disease; eye disorders such as …