Mitochondrial complex I as a pathologic and therapeutic target for Parkinson's disease

KP Tryphena, US Nikhil, P Pinjala… - ACS Chemical …, 2023 - ACS Publications
The prevalence of Parkinson's disease (PD) continues to increase despite substantial
research. Mounting evidence states that dysfunctional mitochondrial bioenergetics play a …

Integration of miRNA's theranostic potential with nanotechnology: promises and challenges for Parkinson's disease therapeutics

KP Tryphena, G Singh, N Jain, P Famta… - Mechanisms of Ageing …, 2023 - Elsevier
Despite the wide research going on in Parkinson's disease (PD), the burden of PD still
remains high and continues to increase. The current drugs available for the treatment of PD …

Mitochondrial quality control in the brain: The physiological and pathological roles

X Shen, P Sun, H Zhang, H Yang - Frontiers in Neuroscience, 2022 - frontiersin.org
The human brain has high energetic expenses and consumes over 20% of total oxygen
metabolism. Abnormal brain energy homeostasis leads to various brain diseases. Among …

Tunneling nanotubes and mesenchymal stem cells: New insights into the role of melatonin in neuronal recovery

F Luchetti, S Carloni, MG Nasoni… - Journal of pineal …, 2022 - Wiley Online Library
Efficient cell‐to‐cell communication is essential for tissue development, homeostasis, and
the maintenance of cellular functions after injury. Tunneling nanotubes (TNTs) have …

Understanding the involvement of microRNAs in mitochondrial dysfunction and their role as potential biomarkers and therapeutic targets in Parkinson's disease

KP Tryphena, U Anuradha, R Kumar… - Journal of …, 2023 - content.iospress.com
Parkinson's disease (PD) is the second most common neurodegenerative disease, affecting
the elderly worldwide and causing significant movement impairments. The goal of PD …

Therapeutic potential of targeting mitochondria for Alzheimer's disease treatment

A Atlante, G Amadoro, V Latina, D Valenti - Journal of Clinical Medicine, 2022 - mdpi.com
Alzheimer's disease (AD), a chronic and progressive neurodegenerative disease, is
characterized by memory and cognitive impairment and by the accumulation in the brain of …

Impacts of impaired mitochondrial dynamics in hearing loss: Potential therapeutic targets

T Zou, B Ye, K Chen, A Zhang, D Guo, Y Pan… - Frontiers in …, 2022 - frontiersin.org
Mitochondria are the powerhouse of the cells. Under physiological conditions, mitochondrial
fission and fusion maintain a dynamic equilibrium in the cytoplasm, which is referred to as …

Decreased mitochondrial D-loop region methylation mediates an increase in mitochondrial DNA copy number in CADASIL

J Zhang, J Shang, F Wang, X Huo, R Sun, Z Ren… - Clinical …, 2022 - Springer
Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL) is a typical neurodegenerative disease associated with …

The interplay between prior selection, mild intermittent exposure, and acute severe exposure in phenotypic and transcriptional response to hypoxia

MN Ekwudo, MC Malek, CE Anderson… - Ecology and …, 2022 - Wiley Online Library
Hypoxia has profound and diverse effects on aerobic organisms, disrupting oxidative
phosphorylation and activating several protective pathways. Predictions have been made …

Exercise Epigenetics is fueled by cell Bioenergetics: Supporting role on Brain Plasticity and Cognition

F Gomez-Pinilla, P Thapak - Free Radical Biology and Medicine, 2024 - Elsevier
Exercise has the unique aptitude to benefit overall health of body and brain. Evidence
indicates that the effects of exercise can be saved in the epigenome for considerable time to …