The possible link between hIAPP accumulation and β-cell death in diabetic patients has
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …

Mitochondrial reactive oxygen species (ROS) production and detoxification are tightly
balanced. Shifting this balance enables ROS to activate intracellular signaling and/or induce …

Macronutrients–carbohydrates, fats, and proteins–supply the nutrients required for optimal
functioning. Inadequate intake compromises both physical and brain health. We synthesized …

Insulin resistance in skeletal muscle is manifested by decreased insulin‐stimulated glucose
uptake and results from impaired insulin signaling and multiple post‐receptor intracellular …

A discussion of the pathogenesis of type 2 diabetes mellitus must start with a review of
mechanisms involved in the maintenance of normal glucose homeostasis in the basal or …

The heart is adapted to utilize all classes of substrates to meet the high-energy demand, and
it tightly regulates its substrate utilization in response to environmental changes. Although …

Type 2 diabetes mellitus is characterised by resistance of peripheral tissues to insulin and a
relative deficiency of insulin secretion. To find out which is the earliest or primary …

The two main sodium–glucose cotransporters (SGLTs), SGLT1 and SGLT2, provide new
therapeutic targets to reduce hyperglycaemia in patients with diabetes. SGLT1 enables the …

Malignant cells are known to have accelerated metabolism, high glucose requirements, and
increased glucose uptake. Transport of glucose across the plasma membrane of …

The dihydrochalcone phlorizin is a natural product and dietary constituent found in a number
of fruit trees. It has been used as a pharmaceutical and tool for physiology research for over …