A “foldamer” is an artificial oligomeric molecule with a regular secondary or tertiary structure
consisting of various building blocks. A “stapled peptide” is a peptide with stabilized …

A model system is introduced as a general tool to elaborate on orthogonal templation of
dynamic covalent ring‐opening polymerization (ODC‐TROP). The tool consists of 310 …

We present an E-selective ring-closing metathesis reaction in α-helical stapled peptides at
positions i and i+ 4. The use of two chiral carbocyclic α, α-disubstituted α-amino acids,(1 S, 3 …

Nowadays, design of the new chiral ligands for organometallic catalysts is often based on
the step-by-step increase in their complexity to improve efficiency. Herein we describe that …

Peptides and foldamers have recently gained increasing attention as chiral catalysts to
achieve challenging (asymmetric) transformations. We previously reported that short …

Conformational freedom-restricted peptides, such as stapled peptides, play a crucial role in
the advancement of functional peptide development. We synthesized stapled octapeptides …

Enantioselective catalytic formation of polyfunctional molecules, such as non‐natural amino
acids, is important for the efficient production of many chiral compounds. To this end, we …

Juliá and Colonna were one of the firsts chemists reporting examples of enantioselective
organocatalyzed reactions, namely the Phase-Transfer Catalysis (PTC) olefin epoxidation …

Enzymes are some of nature's most powerful tools in chemical processes. However, their
molecular complexity makes them difficult to synthesize and complicates their application in …

In general, the Pinder reaction concerns the reaction between an enolisable anhydride and
an aldehyde proceeding initially through a Knoevenagel reaction followed by the ring …