Mechanisms of vertebrate DNA interstrand cross-link repair
DNA interstrand cross-links (ICLs) covalently connect the two strands of the double helix and
are extremely cytotoxic. Defective ICL repair causes the bone marrow failure and cancer …
are extremely cytotoxic. Defective ICL repair causes the bone marrow failure and cancer …
Understanding cancer and the anticancer activities of naphthoquinones–a review
KW Wellington - RSC advances, 2015 - pubs.rsc.org
The non-communicable disease, cancer, is one of the major causes of death across the
world and is forecast to increase by 75% to reach close to 25 million cases over the next two …
world and is forecast to increase by 75% to reach close to 25 million cases over the next two …
Sequence-based design of bioactive small molecules that target precursor microRNAs
Oligonucleotides are designed to target RNA using base pairing rules, but they can be
hampered by poor cellular delivery and nonspecific stimulation of the immune system. Small …
hampered by poor cellular delivery and nonspecific stimulation of the immune system. Small …
An overview of chemical processes that damage cellular DNA: spontaneous hydrolysis, alkylation, and reactions with radicals
KS Gates - Chemical research in toxicology, 2009 - ACS Publications
The sequence of heterocyclic bases on the interior of the DNA double helix constitutes the
genetic code that drives the operation of all living organisms. With this said, it is not …
genetic code that drives the operation of all living organisms. With this said, it is not …
ortho-Quinone methide (o-QM): a highly reactive, ephemeral and versatile intermediate in organic synthesis
MS Singh, A Nagaraju, N Anand, S Chowdhury - RSC advances, 2014 - pubs.rsc.org
Since its first observation in 1907, ortho-quinone methide (o-QM) has occupied a strategic
place within the framework of reactive intermediates in organic synthesis. In recent years, o …
place within the framework of reactive intermediates in organic synthesis. In recent years, o …
Electrophilic natural products and their biological targets
Covering: 1900 to 2011 The study of biologically active natural products has resulted in
seminal contributions to our understanding of living systems. In the case of electrophilic …
seminal contributions to our understanding of living systems. In the case of electrophilic …
Recent advances in the asymmetric synthesis of pharmacology-relevant nitrogen heterocycles via stereoselective aza-Michael reactions
MG Vinogradov, OV Turova, SG Zlotin - Organic & Biomolecular …, 2019 - pubs.rsc.org
The prevalence of nitrogen containing heterocycles in natural products and pharmaceuticals
is a doubtless fact. In this review, recent applications of a stereoselective aza-Michael …
is a doubtless fact. In this review, recent applications of a stereoselective aza-Michael …
Enzymatic chemistry of cyclopropane, epoxide, and aziridine biosynthesis
Cyclopropane, epoxide, and aziridine groups are three-membered ring structural elements
found in a wide variety of natural products, some of which are depicted in Figure 1. 1 The …
found in a wide variety of natural products, some of which are depicted in Figure 1. 1 The …
ONO-pincer Zn (II) & Cd (II) complexes: Synthesis, structural characterization, Hirshfeld surface analysis and CT-DNA interactions
Four new ONO pincer complexes of type Na 2 [Cd (L′)(OAc) 2](2a), Na 2 [Zn (L)(OAc)
2](3a),[Zn (L Me)(OAc) 2](4a) and [Cd (L Me)(OAc) 2](4b), where L′= N, N'-bis (4 …
2](3a),[Zn (L Me)(OAc) 2](4a) and [Cd (L Me)(OAc) 2](4b), where L′= N, N'-bis (4 …
A new prodrug-derived ratiometric fluorescent probe for hypoxia: high selectivity of nitroreductase and imaging in tumor cell
Based on the hypoxia prodrug moiety of p-nitrobenzyl, a selective ratiometric fluorescent
sensor (RHP) for the detection of microenvironment hypoxia was designed and synthesized …
sensor (RHP) for the detection of microenvironment hypoxia was designed and synthesized …