Importance Chronic kidney disease (CKD) is the 16th leading cause of years of life lost
worldwide. Appropriate screening, diagnosis, and management by primary care clinicians …

Chronic kidney disease (CKD) is defined by persistent urine abnormalities, structural
abnormalities or impaired excretory renal function suggestive of a loss of functional …

La enfermedad renal crónica (ERC) es un importante problema de salud pública a nivel
mundial afectando a más del 10% de la población española. Se asocia a elevada …

Metformin is an oral antihyperglycemic drug widely used to treat type 2 diabetes mellitus
(T2DM), acting via indirect activation of 5′ Adenosine monophosphate-activated Protein …

Type 2 diabetes mellitus (T2DM) represents the main cause of chronic kidney disease
(CKD) and end-stage renal disease (ESKD), and diabetic kidney disease (DKD) is a major …

As the world population ages, an expected increase in the prevalence of chronic kidney
disease (CKD) among older individuals will pose a considerable challenge for health care …

Frailty is a condition that is frequently observed among patients undergoing dialysis. Frailty
is characterized by a decline in both physiological state and cognitive state, leading to a …

Background Various prediction models have been developed to predict the risk of kidney
failure in patients with CKD. However, guideline-recommended models have yet to be …

OBJECTIVE To predict adverse kidney outcomes for use in optimizing medical management
and clinical trial design. RESEARCH DESIGN AND METHODS In this meta-analysis of …

Background External validation of prognostic models is necessary to assess the accuracy
and generalizability of the model to new patients. If models are validated in a setting in …