Cholesterol is an indispensable component of the cell membrane and plays vital roles in
critical physiological processes. Brain cholesterol accounts for a large portion of total …

Alzheimer's disease (AD) is the most common form of dementia and it is characterized by the
deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain. However, the …

It has been illustrated that metabolic syndrome (MetS) is associated with Alzheimer disease
(AD) neuropathology. Components of MetS including central obesity, hypertension, insulin …

Parkinson's disease (PD) is a neurodegenerative disease due to the degeneration of
dopaminergic neurons (DNs) in the substantia nigra (SN). The liver X receptor (LXR) is …

Abstract Alzheimer's disease (AD), the most frequent cause of dementia, is escalating as a
global epidemic, and so far, there is neither cure nor treatment to alter its progression. The …

Alzheimer's disease (AD), the most common neurodegenerative disorder associated with
dementia, is typified by the pathological accumulation of amyloid Aβ peptides and …

The activation of the brain renin-angiotensin system (RAS) plays a pivotal role in the
pathophysiology of cognition. While the brain RAS has been studied before in the context of …

The successful treatment of Alzheimer's disease (AD) will require drugs that can negotiate
the blood–brain barrier (BBB). However, the BBB is not simply a physical barrier, but a …

In the central nervous system cholesterol is involved in membrane structure and function.
Since the blood–brain barrier efficiently prevents cholesterol uptake from the circulation, de …

The development of Alzheimer's disease (AD) is influenced by several events, among which
the dysregulation of cholesterol metabolism in the brain plays a major role. Maintenance of …