Biosynthesis and synthetic biology of psychoactive natural products

CS Jamieson, J Misa, Y Tang… - Chemical Society Reviews, 2021 - pubs.rsc.org
Psychoactive natural products play an integral role in the modern world. The tremendous
structural complexity displayed by such molecules confers diverse biological activities of …

Terpenoid transport in plants: how far from the final picture?

OC Demurtas, A Nicolia, G Diretto - Plants, 2023 - mdpi.com
Contrary to the biosynthetic pathways of many terpenoids, which are well characterized and
elucidated, their transport inside subcellular compartments and the secretion of reaction …

Vacuolar MATE/DTX protein‐mediated cucurbitacin C transport is co‐regulated with bitterness biosynthesis in cucumber

Y Ma, D Li, Y Zhong, X Wang, L Li, A Osbourn… - New …, 2023 - Wiley Online Library
Membrane‐localized transporters constitute important components for specialized
metabolism in plants. However, due to the vast array of specialized metabolites produced by …

Purine permease-type benzylisoquinoline alkaloid transporters in opium poppy

M Dastmalchi, L Chang, R Chen, L Yu, X Chen… - Plant …, 2019 - academic.oup.com
Although opiate biosynthesis has been largely elucidated, and cell-to-cell transport has
been long postulated, benzylisoquinoline alkaloid (BIA) transporters from opium poppy …

Utilizing plant synthetic biology to improve human health and wellness

CR Barnum, BJ Endelman, PM Shih - Frontiers in Plant Science, 2021 - frontiersin.org
Plants offer a vast source of bioactive chemicals with the potential to improve human health
through the prevention and treatment of disease. However, many potential therapeutics are …

Deorphanizing solute carriers in Saccharomyces cerevisiae for secondary uptake of xenobiotic compounds

I Møller-Hansen, J Sáez-Sáez… - Frontiers in …, 2024 - frontiersin.org
The exchange of small molecules between the cell and the environment happens through
transporter proteins. Besides nutrients and native metabolic products, xenobiotic molecules …

Developmental Methylome of the Medicinal Plant Catharanthus roseus Unravels the Tissue-Specific Control of the Monoterpene Indole Alkaloid Pathway by DNA …

T Dugé de Bernonville, S Maury, A Delaunay… - International Journal of …, 2020 - mdpi.com
Catharanthus roseus produces a wide spectrum of monoterpene indole alkaloids (MIAs).
MIA biosynthesis requires a tightly coordinated pathway involving more than 30 enzymatic …

Diurnal metabolic regulation of isoflavones and soyasaponins in soybean roots

H Matsuda, M Nakayasu, Y Aoki, S Yamazaki… - Plant …, 2020 - Wiley Online Library
Isoflavones and soyasaponins are major specialized metabolites accumulated in soybean
roots and secreted into the rhizosphere. Unlike the biosynthetic pathway, the transporters …

CrJAT1 Regulates Endogenous JA Signaling for Modulating Monoterpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus

M Zhang, B Yang, Y Wang, F Yu - Genes, 2024 - mdpi.com
Many monoterpenoid indole alkaloids (MIAs) produced in Catharanthus roseus have
demonstrated biological activities and clinical potential. However, their complex …

The Vinca minor genome highlights conserved evolutionary traits in monoterpene indole alkaloid synthesis

EA Stander, C Cuello, C Birer-Williams, N Kulagina… - G3, 2022 - academic.oup.com
Vinca minor, also known as the lesser periwinkle, is a well-known species from the
Apocynaceae, native to central and southern Europe. This plant synthesizes monoterpene …