Platelets are anucleate cells produced by megakaryocytes. In recent years, a robust body of
literature supports the evolving role of platelets as key sentinel and effector cells in infectious …

Platelets are essential effector cells in hemostasis. Aside from their role in coagulation,
platelets are now recognized as major inflammatory cells with key roles in the innate and …

Lipid droplets (LDs) contribute to key pathways important for the physiology and
pathophysiology of cells. In a homeostatic view, LDs regulate the storage of neutral lipids …

Endothelial dysfunction leading to vascular leak is the hallmark of severe dengue. Vascular
leak typically becomes clinically evident 3–6 days after the onset of illness, which is known …

Abstract Introduction Sphingosine-1-phosphate (S1P) is a signaling lipid that regulates
pathophysiological processes involved in sepsis progression, including endothelial …

Sphingolipids are essential components of all eukaryotic membranes. The bioactive
sphingolipid molecule, Sphingosine 1-Phosphate (S1P), regulates various important …

The currently spreading arbovirus epidemic is having a severe impact on human health
worldwide. The two most common flaviviruses, dengue virus (DENV) and Zika virus (ZIKV) …

Dengue is the most rapidly emerging climate-sensitive infection, and morbidity/mortality and
disease incidence are rising markedly, leading to healthcare systems being overwhelmed …

Platelets have classically been considered crucial effector cells in hemostasis, but now are
increasingly recognized as players during inflammatory responses in innate and adaptive …

Sepsis is an acute life-threatening multiple organ failure caused by a dysregulated host
response to infection. Endothelial dysfunction, particularly barrier disruption leading to …