The anti-viral facet of anti-rheumatic drugs: Lessons from COVID-19
The outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection has posed the world at a pandemic risk. Coronavirus-19 disease (COVID-19) is an …
infection has posed the world at a pandemic risk. Coronavirus-19 disease (COVID-19) is an …
Host-directed antiviral therapy
Antiviral drugs have traditionally been developed by directly targeting essential viral
components. However, this strategy often fails due to the rapid generation of drug-resistant …
components. However, this strategy often fails due to the rapid generation of drug-resistant …
Therapeutic strategies to target the Ebola virus life cycle
Following the Ebola virus disease epidemic in west Africa, there has been increased
awareness of the need for improved therapies for emerging diseases, including viral …
awareness of the need for improved therapies for emerging diseases, including viral …
Structural and functional aspects of Ebola virus proteins
S Jain, E Martynova, A Rizvanov, S Khaiboullina… - Pathogens, 2021 - mdpi.com
Ebola virus (EBOV), member of genus Ebolavirus, family Filoviridae, have a non-segmented,
single-stranded RNA that contains seven genes:(a) nucleoprotein (NP),(b) viral protein 35 …
single-stranded RNA that contains seven genes:(a) nucleoprotein (NP),(b) viral protein 35 …
COVID-19 in teriflunomide-treated patients with multiple sclerosis
AH Maghzi, MK Houtchens, P Preziosa, C Ionete… - Journal of …, 2020 - Springer
The outbreak of a severe acute respiratory syndrome caused by a novel coronavirus (COVID-
19), has raised health concerns for patients with multiple sclerosis (MS) who are commonly …
19), has raised health concerns for patients with multiple sclerosis (MS) who are commonly …
Lipid delivery systems for nucleic-acid-based-drugs: From production to clinical applications
AA Barba, S Bochicchio, A Dalmoro, G Lamberti - Pharmaceutics, 2019 - mdpi.com
In the last years the rapid development of Nucleic Acid Based Drugs (NABDs) to be used in
gene therapy has had a great impact in the medical field, holding enormous promise …
gene therapy has had a great impact in the medical field, holding enormous promise …
In silico identification of cassava genome-encoded MicroRNAs with predicted potential for targeting the ICMV-Kerala begomoviral pathogen of cassava
Cassava mosaic disease (CMD) is caused by several divergent species belonging to the
genus Begomovirus (Geminiviridae) transmitted by the whitefly Bemisia tabaci cryptic …
genus Begomovirus (Geminiviridae) transmitted by the whitefly Bemisia tabaci cryptic …
IMU-838, a developmental DHODH inhibitor in phase II for autoimmune disease, shows anti-SARS-CoV-2 and broad-spectrum antiviral efficacy in vitro
F Hahn, C Wangen, S Häge, AS Peter, G Dobler… - Viruses, 2020 - mdpi.com
The ongoing pandemic spread of the severe acute respiratory syndrome coronavirus type 2
(SARS-CoV-2) demands skillful strategies for novel drug development, drug repurposing …
(SARS-CoV-2) demands skillful strategies for novel drug development, drug repurposing …
A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus
There are no approved therapies for Ebola virus infection. Here, to find potential therapeutic
targets, we perform a screen for genes essential for Ebola virus (EBOV) infection. We identify …
targets, we perform a screen for genes essential for Ebola virus (EBOV) infection. We identify …
Utility of leflunomide in the treatment of complex cytomegalovirus syndromes
RK Avery, SB Mossad, E Poggio, M Lard… - …, 2010 - journals.lww.com
Background. Cytomegalovirus (CMV) viremia that is resistant or refractory to the standard
antiviral therapy still constitutes a major threat to high-risk transplant recipients. In addition …
antiviral therapy still constitutes a major threat to high-risk transplant recipients. In addition …