This review discusses the need for tracheal replacement, distinct from resection with primary
anastomosis, the requirements for replacement, and the many efforts over the past century to …

This paper reviews hypotheses about roles of angiogenesis in the pathogenesis of
inflammatory disease in two organs, the synovial joint and the lung. Neovascularisation is a …

Background. Bronchiolitis obliterans is the most significant complication adversely affecting
prolonged survival of lung allograft recipients. The evolution from the initial insult to the final …

Background. Because epithelial cells are targets of alloimmune injury leading ultimately to
airway obliteration, we tested whether epithelial re-growth could prevent obliterative airway …

The challenge of the treatment of end‐stage lung disease poses an urgent clinical demand
for lung tissue engineering. Over the past few years, various lung tissue‐engineered …

Replacement of the tracheal conduit remains a difficult and unresolvedsurgical problem. We
present an experimental study of 20 pigs undergoingreplacement of the cervical trachea …

Heterotopic tracheal allografts in small rodents have been shown to share many
characteristics with the development of obliterative bronchiolitis (OB) in the clinic and …

We investigated the effects of allograft perfusion with a preservative technique and of
combined thyrotracheoesophageal implantation on airway epithelium of long segments of …

A macrosurgical technique of thyrotracheal harvesting and direct revascularization with and
without venous drainage in a heterotopic thyrotracheal and immunosuppressed allograft in …

Ischemic airway complications after lung transplantation remain a significant problem
despite the use of bronchial omentopexy. Clinical observations suggest that enhancement of …