The total mass, number, and distribution of immune cells in the human body

R Sender, Y Weiss, Y Navon, I Milo… - Proceedings of the …, 2023 - National Acad Sciences
The immune system is a complex network of cells with critical functions in health and
disease. However, a comprehensive census of the cells comprising the immune system is …

Splenomegaly in children and adolescents

M Suttorp, CF Classen - Frontiers in pediatrics, 2021 - frontiersin.org
In contrast to other lymphoid tissues making up the immune system, the spleen as its biggest
organ is directly linked into the blood circulation. Beside its main task to filter out …

Lessons learned from the clinical presentation of common variable immunodeficiency disorders: a systematic review and meta-analysis

LMA Janssen, M van der Flier, E de Vries - Frontiers in immunology, 2021 - frontiersin.org
Background Diagnostic delay in common variable immunodeficiency disorders (CVID) is
considerable. There is no generally accepted symptom-recognition framework for its early …

Piperlongumine regulates epigenetic modulation and alleviates psoriasis-like skin inflammation via inhibition of hyperproliferation and inflammation

S Thatikonda, V Pooladanda, DK Sigalapalli… - Cell death & …, 2020 - nature.com
Psoriasis is an autoimmune skin disease, where chronic immune responses due to
exaggerated cytokine signaling, abnormal differentiation, and evasion of keratinocytes …

A BCG kill switch strain protects against Mycobacterium tuberculosis in mice and non-human primates with improved safety and immunogenicity

AA Smith, H Su, J Wallach, Y Liu, P Maiello… - Nature …, 2025 - nature.com
Improved vaccination strategies for tuberculosis are needed. Intravenous (iv) delivery of live
attenuated Mycobacterium bovis BCG provides protection against Mycobacterium …

Intermittent rapamycin feeding recapitulates some effects of continuous treatment while maintaining lifespan extension

M Baghdadi, T Nespital, C Monzó, J Deelen… - Molecular …, 2024 - Elsevier
Objective Rapamycin, a powerful geroprotective drug, can have detrimental effects when
administered chronically. We determined whether intermittent treatment of mice can reduce …

Valoctocogene roxaparvovec gene therapy provides durable haemostatic control for up to 7 years for haemophilia A

E Symington, S Rangarajan, W Lester, B Madan… - …, 2024 - Wiley Online Library
Introduction Valoctocogene roxaparvovec is an adeno‐associated virus vector serotype 5
(AAV5)‐mediated gene therapy approved for severe haemophilia A (HA). Aim To report the …

Does COVID-19 cause an increase in spleen dimensions? Possible effects of immune activation, hematopoietic suppression and microthrombosis

M Tahtabasi, T Hosbul, E Karaman, Y Akin… - Clinical imaging, 2021 - Elsevier
Purpose To radiologically examine how the spleen size, which has important functions in
hematological and immunological balance, is affected in COVID-19. Methods Between July …

Splenic Complications of Babesia microti Infection in Humans: A Systematic Review

I Dumic, C Madrid, L Rueda Prada… - Canadian Journal of …, 2020 - Wiley Online Library
Splenic complications of acute Babesia microti infection include splenomegaly, splenic
infarct, and splenic rupture. These complications are relatively rarely reported, and the aim …

[PDF][PDF] Ultrasound criteria of splenomegaly

V Izranov, U Palvanova, V Gordova… - The …, 2019 - medtextpublications.com
The aim of the study was to compare the linear measurements of the spleen (length, width,
thickness), volume, mass and spleen mass coefficient in volunteers and correlate these …