Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Adenosine deaminase acting on RNA (ADAR) catalyzes the posttranscriptional conversion
of adenosine to inosine in double‐stranded RNA (dsRNA), which can lead to the creation of …

Aging is a biological process characterized by a progressive functional decline in tissues
and organs, which eventually leads to mortality. Telomeres, the repetitive DNA repeat …

Telomerase negative immortal cancer cells elongate telomeres through the Alternative
Lengthening of Telomeres (ALT) pathway. While sustained telomeric replicative stress is …

R-loop structures act as modulators of physiological processes such as transcription
termination, gene regulation, and DNA repair. However, they can cause transcription …

Abstract Alternative Lengthening of Telomeres (ALT) is a Break-Induced Replication (BIR)-
based mechanism elongating telomeres in a subset of human cancer cells. While the notion …

ADAR1 is involved in adenosine-to-inosine RNA editing. The cytoplasmic ADAR1p150 edits
3'UTR double-stranded RNAs and thereby suppresses induction of interferons. Loss of this …

Telomeres protect chromosome ends from nucleolytic degradation, uncontrolled
recombination by DNA repair enzymes and checkpoint signaling, and they provide …

TERRA is a class of telomeric repeat-containing RNAs that are expressed from telomeres in
multiple organisms. TERRA transcripts play key roles in telomere maintenance and their …

Telomeres, also known as the “protective caps” of our chromosomes, shorten with each cell
cycle due to the end replication problem. This process, termed telomere attrition, is …