In recent years, nanopore technology has become increasingly important in the field of life
science and biomedical research. By embedding a nano-scale hole in a thin membrane and …

Sequencing technologies have placed a wide range of genomic analyses within the
capabilities of many laboratories. However, sequencing costs often set limits to the amount …

Patients with cancer carry somatic sequence variants in their tumour in addition to the
germline variants in their inherited genome. Although variants in protein-coding regions …

DNA double-strand breaks (DSBs) are common lesions that continually threaten genomic
integrity. Failure to repair a DSB has deleterious consequences, including cell death …

The realization, now more than half a century ago, that B cells can generate antibodies to an
astounding variety of chemical structures sparked intense interest in the “generation of …

Genome editing with engineered nucleases is a rapidly growing field thanks to
transformative technologies that allow researchers to precisely alter genomes for numerous …

DNA double-strand breaks (DSBs) are highly toxic lesions that can be mended via several
DNA repair pathways. Multiple factors can influence the choice and the restrictiveness of …

DNA double-strand breaks (DSBs) are commonly seen as lesions that threaten genome
integrity and contribute to cancer and aging processes. However, in the context of antigen …

DNA double-stranded breaks (DSBs) can be repaired by several mechanisms, including
classical NHEJ (c-NHEJ) and a poorly defined, error-prone process termed alternative NHEJ …

Over the last 10 years, next‐generation sequencing (NGS) has transformed genomic
research through substantial advances in technology and reduction in the cost of …