Switching reversibility to irreversibility in glycogen synthase kinase 3 inhibitors: clues for specific design of new compounds
DI Perez, V Palomo, C Pérez, C Gil… - Journal of Medicinal …, 2011 - ACS Publications
Development of kinase-targeted therapies for central nervous system (CNS) diseases is a
great challenge. Glycogen synthase kinase 3 (GSK-3) offers a great potential for severe …
great challenge. Glycogen synthase kinase 3 (GSK-3) offers a great potential for severe …
Synthesis of α-Hydroxyacetophenones
M McLaughlin, KM Belyk, G Qian… - The Journal of …, 2012 - ACS Publications
A general method for the preparation of α-hydroxyacetophenones is presented.
Functionalized arylmagnesium species are transmetalated to the corresponding arylzinc …
Functionalized arylmagnesium species are transmetalated to the corresponding arylzinc …
Substituent effects on the stereochemical outcome of the baker's yeast-mediated biotransformation of α-hydroxy-and α-acetoxymethyl-5-phenylfuran-2-yl-ethanones
In this Letter the baker's yeast-mediated biotransformation of variously substituted α-hydroxy-
and α-acetoxymethyl-5-phenylfuran-2-yl-ethanones is described. The stereochemical …
and α-acetoxymethyl-5-phenylfuran-2-yl-ethanones is described. The stereochemical …
Baker's yeast-mediated synthesis of (R)-and (S)-heteroaryl-ethane-1, 2-diols
Baker’s yeast-mediated synthesis of (R)- and (S)-heteroaryl-ethane-1,2-diols - ScienceDirect
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Silver acetate mediated acetoxylations of alkyl halides
R Nolla-Saltiel, UA Carrillo-Arcos, S Porcel - Synthesis, 2014 - thieme-connect.com
Silver acetate promotes the acetoxylation of alkyl halides under neutral reaction conditions.
The reaction is applicable to primary and activated secondary alkyl halides, and 2, 2 …
The reaction is applicable to primary and activated secondary alkyl halides, and 2, 2 …
Batch, semi-continuous or continuous hydrochlorination of glycerin with reduced volatile chlorinated hydrocarbon by-products and chloracetone levels
WJ Kruper Jr, T Arrowood, BM Bell, J Briggs… - US Patent …, 2011 - Google Patents
The present invention relates to a process for converting a multihydroxylated-aliphatic
hydrocarbon or ester thereof to a chlorohydrin, by contacting the multihydroxylated-aliphatic …
hydrocarbon or ester thereof to a chlorohydrin, by contacting the multihydroxylated-aliphatic …
The discovery and synthesis of the CGRP receptor antagonist MK-3207
IM Bell, PG Bulger, M McLaughlin - Comprehensive Accounts of …, 2016 - ACS Publications
Calcitonin gene-related peptide (CGRP) is a potent vasodilator and neuromodulator.
Multiple lines of evidence demonstrate that CGRP plays a key role in the pathogenesis of …
Multiple lines of evidence demonstrate that CGRP plays a key role in the pathogenesis of …
Microwave-assisted one-carbon chain extension in the preparation of terminal α-hydroxy ketones
MJP Vaismaa, MV Leskinen… - Synthetic Communications …, 2009 - Taylor & Francis
The microwave-assisted synthesis of terminal α-hydroxy ketones from acid chlorides and tris
(trimethylsiloxy) ethylene in the presence of triethylamine is reported. The use of …
(trimethylsiloxy) ethylene in the presence of triethylamine is reported. The use of …
Batch, semi-continuous or continuous hydrochlorination of glycerin with reduced volatile chlorinated hydrocarbon by-products and chloroacetone levels
WJ Kruper, T Arrowood, BM Bell, J Briggs… - US Patent …, 2013 - Google Patents
The present invention relates to a process for converting a multihydroxylated-aliphatic
hydrocarbon or ester thereof to a chlorohydrin, by contacting the multihydroxylated-aliphatic …
hydrocarbon or ester thereof to a chlorohydrin, by contacting the multihydroxylated-aliphatic …
A simple synthesis of 4-substituted 2-(3-hydroxy-2-oxo-1-phenethylpropylcarbamoyl) pyrrolidine-1-carboxylic acid benzyl esters as novel cysteine protease inhibitors
S Oh, JC Jung, MA Avery - Zeitschrift für Naturforschung B, 2008 - degruyter.com
A convenient synthesis of 4-substituted 2-(3-hydroxy-2-oxo-1-phenethylpropylcarbamoyl)
pyrrolidine-1-carboxylic acid benzyl esters 17 and 18 as new cysteine protease inhibitors is …
pyrrolidine-1-carboxylic acid benzyl esters 17 and 18 as new cysteine protease inhibitors is …