Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics
currently in clinical use and only a few novel drugs in the pipeline. Understanding the …

Klebsiella pneumoniae is a common cause of antimicrobial-resistant opportunistic infections
in hospitalized patients. The species is naturally resistant to penicillins, and members of the …

Hypervirulence and carbapenem resistance have emerged as two distinct evolutionary
directions for Klebsiella pneumoniae, which pose a great threat in clinical settings. Multiple …

Klebsiella pneumoniae has emerged as an important cause of two distinct public health
threats: multi-drug resistant (MDR) healthcare-associated infections and drug susceptible …

Bacterial conjugation mediates contact-dependent transfer of DNA from donor to recipient
bacteria, thus facilitating the spread of virulence and resistance plasmids. Here we describe …

The emergence of antimicrobial-resistant bacteria is an increasingly serious threat to global
health, necessitating the development of innovative antimicrobials. Here we report the …

Highlights•Multi-drug resistance in E. coli and K. pneumoniae is concentrated in a small
number of globally disseminated clones.•Certain plasmids are associated with ESBL and …

Rresistance-nodulation-division (RND) efflux pumps in Gram-negative bacteria remove
multiple, structurally distinct classes of antimicrobials from inside bacterial cells therefore …

Although hypervirulent Klebsiella pneumoniae (hvKP) can produce community-acquired
infections that are fatal in young and adult hosts, such as pyogenic liver abscess …

Currently, the efficacy of antibiotics is severely affected by the emergence of the
antimicrobial resistance phenomenon, leading to increased morbidity and mortality …