Inflammatory bowel disease (IBD) is a chronic, relapsing gastrointestinal (GI) disorder
characterized by intestinal inflammation. The etiology of IBD is multifactorial and results from …

Preclinical biomedical research is limited by the predictiveness of in vivo and in vitro models.
While in vivo models offer the most complex system for experimentation, they are also …

A key component of efforts to identify the biological and drug-specific aspects contributing to
therapeutic failure or unexpected exposure-associated toxicity is the study of drug–intestinal …

Sepsis is a potentially fatal condition characterized by organ dysfunction caused by an
imbalanced immune response to infection. Although an increased inflammatory response …

Organoids are in vitro organ-like structures that faithfully recapitulate many characteristics of
a specific organ. During the past decades, major progress has been accomplished in …

First year medical and veterinary students are made very aware that drugs can have very
different effects in various species or even in breeds of one specific species. On the other …

Epithelial damage due to gastrointestinal disorders frequently causes severe disease in
horses. To study the underlying pathophysiological processes, we aimed to establish equine …

Abstract Organoids are 3-dimensional (3D) self-assembled structures capable of replicating
the microanatomy and physiology of the epithelial components of their organ of origin. Adult …

Gastrointestinal disease is a leading cause of death in mature horses. A lack of in vitro
modeling has impeded the development of novel therapeutics. The objectives of this study …

The etiology of gastrointestinal (GI) diseases is intricate and multifactorial, encompassing
complex interactions between genetic predisposition and gut microbiota. The cell fate …