The biology, function, and biomedical applications of exosomes
BACKGROUND All cells, prokaryotes and eukaryotes, release extracellular vesicles (EVs)
as part of their normal physiology and during acquired abnormalities. EVs can be broadly …
as part of their normal physiology and during acquired abnormalities. EVs can be broadly …
Emerging prospects of exosomes for cancer treatment: from conventional therapy to immunotherapy
Exosomes are a class of extracellular vesicles of around 100 nm in diameter that are
secreted by most cells and contain various bioactive molecules reflecting their cellular origin …
secreted by most cells and contain various bioactive molecules reflecting their cellular origin …
[HTML][HTML] Mesenchymal stem cell-derived extracellular vesicles ameliorate Alzheimer's disease-like phenotypes in a preclinical mouse model
Alzheimer's disease (AD) is an irreversible neurodegenerative disorder that affects more
than 44 million people worldwide. Despite the high disease burden, there is no effective …
than 44 million people worldwide. Despite the high disease burden, there is no effective …
Intranasal delivery of mesenchymal stem cell derived exosomes loaded with phosphatase and tensin homolog siRNA repairs complete spinal cord injury
Individuals with spinal cord injury (SCI) usually suffer from permanent neurological deficits,
while spontaneous recovery and therapeutic efficacy are limited. Here, we demonstrate that …
while spontaneous recovery and therapeutic efficacy are limited. Here, we demonstrate that …
High-quality milk exosomes as oral drug delivery system
Many drugs must be administered intravenously instead of oral administration due to their
poor oral bioavailability. The cost of repeated infusion treatment for 6 weeks every year is as …
poor oral bioavailability. The cost of repeated infusion treatment for 6 weeks every year is as …
Boosting extracellular vesicle secretion
In recent years, extracellular vesicles (EVs), specifically exosomes, have emerged as a
promising strategy for treating a wide spectrum of pathologies, such as cancer and COVID …
promising strategy for treating a wide spectrum of pathologies, such as cancer and COVID …
Golden exosomes selectively target brain pathologies in neurodegenerative and neurodevelopmental disorders
Exosomes, nanovesicles that are secreted by different cell types, enable intercellular
communication at local or distant sites. Alhough they have been found to cross the blood …
communication at local or distant sites. Alhough they have been found to cross the blood …
Exosome: a significant nano-scale drug delivery carrier
H Peng, W Ji, R Zhao, J Yang, Z Lu, Y Li… - Journal of Materials …, 2020 - pubs.rsc.org
In recent years, due to the limitations of the nature of therapeutic agents, many synthetic
nano-delivery systems have emerged to enhance the efficacy of drugs. Extracellular vesicles …
nano-delivery systems have emerged to enhance the efficacy of drugs. Extracellular vesicles …
Engineered exosomes with a photoinducible protein delivery system enable CRISPR-Cas–based epigenome editing in Alzheimer's disease
Effective intracellular delivery of therapeutic proteins can potentially treat a wide array of
diseases. However, efficient delivery of functional proteins across the cell membrane …
diseases. However, efficient delivery of functional proteins across the cell membrane …
Intranasal delivery of mesenchymal stem cell-derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's …
M Losurdo, M Pedrazzoli, C D'Agostino… - Stem cells …, 2020 - academic.oup.com
The critical role of neuroinflammation in favoring and accelerating the pathogenic process in
Alzheimer's disease (AD) increased the need to target the cerebral innate immune cells as a …
Alzheimer's disease (AD) increased the need to target the cerebral innate immune cells as a …